ID   A0A2P2E280_9LEPT        Unreviewed;       533 AA.
AC   A0A2P2E280;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Guanosine-5'-triphosphate, 3'-diphosphatepyrophosphatase {ECO:0000313|EMBL:GBF50959.1};
GN   Name=gppA {ECO:0000313|EMBL:GBF50959.1};
GN   ORFNames=LPTSP4_24900 {ECO:0000313|EMBL:GBF50959.1};
OS   Leptospira ryugenii.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1917863 {ECO:0000313|EMBL:GBF50959.1, ECO:0000313|Proteomes:UP000245133};
RN   [1] {ECO:0000313|EMBL:GBF50959.1, ECO:0000313|Proteomes:UP000245133}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YH101 {ECO:0000313|EMBL:GBF50959.1,
RC   ECO:0000313|Proteomes:UP000245133};
RA   Nakao R., Masuzawa T.;
RT   "Novel Leptospira species isolated from soil and water in Japan.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GBF50959.1}.
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DR   EMBL; BFBB01000008; GBF50959.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P2E280; -.
DR   OrthoDB; 9814545at2; -.
DR   Proteomes; UP000245133; Unassembled WGS sequence.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR048950; Ppx_GppA_C.
DR   InterPro; IPR003695; Ppx_GppA_N.
DR   InterPro; IPR030673; PyroPPase_GppA_Ppx.
DR   PANTHER; PTHR30005; EXOPOLYPHOSPHATASE; 1.
DR   PANTHER; PTHR30005:SF0; RETROGRADE REGULATION PROTEIN 2; 1.
DR   Pfam; PF02541; Ppx-GppA; 1.
DR   Pfam; PF21447; Ppx-GppA_III; 1.
DR   PIRSF; PIRSF001267; Pyrophosphatase_GppA_Ppx; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245133}.
FT   DOMAIN          41..323
FT                   /note="Ppx/GppA phosphatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02541"
FT   DOMAIN          339..500
FT                   /note="Ppx/GppA phosphatase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21447"
SQ   SEQUENCE   533 AA;  60004 MW;  DA5D84F237C2A595 CRC64;
     MIPLGQRFKS RLQAESKERI LAAIDLGTNS FHIVIVKVRL DGTLESLTKE KETVRLGSGS
     ADYAVIQEDA FDRGIACLKR FKTLADSYKA DIRAVATSAL REAENRDVFL RRAEIEVGLK
     IDVISGNEEA RLIYLGILQG LPLYEKRILM IDIGGGSTEL LVGEKGEILF SSSLKLGAIR
     LTEKFLKKDP ITALDLQKCK IHIESVLSAF IPQIEPWKPF TVVGSSGTVT SLASMILEKA
     GEKRERLNGY EFRYDQFKEV KKHLLEADTV KKRLKLPGLE SKRADIIVGG LLVLDEVLHR
     LKAQSVTVSD FALRDGIVYD TIESYFRLES SPVPELGNIR EKAIKTIANL YPNGKAHAKQ
     VTLLTLQLFD DLKDVHKLGG VEREYLEAAC HLHQVGLCIS HHSYHKHSYY IIRHSDAMVG
     FSNAEIEIIA LIARYHRKGG PKQKHEEFKV LRPEDQLLVK KLAALLRIGD GLDRSETSIL
     NSVSAKVIGN RVICELFHDK NKDPHLELWS VEEKKDLFEN TFPFQIEFVS VMK
//