ID   A0A2P2EDX3_9PROT        Unreviewed;       532 AA.
AC   A0A2P2EDX3;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=PbB2_02947 {ECO:0000313|EMBL:GBF59255.1};
OS   Candidatus Phycosocius bacilliformis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacterales incertae sedis; Phycosocius.
OX   NCBI_TaxID=1445552 {ECO:0000313|EMBL:GBF59255.1, ECO:0000313|Proteomes:UP000245086};
RN   [1] {ECO:0000313|EMBL:GBF59255.1, ECO:0000313|Proteomes:UP000245086}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BOTRYCO-2 {ECO:0000313|EMBL:GBF59255.1,
RC   ECO:0000313|Proteomes:UP000245086};
RA   Tanabe Y., Yamaguchi H., Watanabe M.M.;
RT   "Draft Genome Sequence of "Candidatus Phycosocius bacilliformis," an
RT   Alphaproteobacterial Ectosymbiont of the Hydrocarbon-Producing Green Alga
RT   Botryococcus braunii.";
RL   Genome Announc. 6:e00396-18(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GBF59255.1}.
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DR   EMBL; BFBR01000011; GBF59255.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P2EDX3; -.
DR   REBASE; 263327; M.PbaCO2ORF2947P.
DR   OrthoDB; 9806213at2; -.
DR   Proteomes; UP000245086; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR   PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:GBF59255.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245086};
KW   Transferase {ECO:0000313|EMBL:GBF59255.1}.
FT   DOMAIN          23..146
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          161..492
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   532 AA;  58461 MW;  76480BD20F4A8A52 CRC64;
     MAGPVKAAGA ARGAAKGGDL GFEAELFKAA DKLRGNMEPS DYKHVALGLI FLKHISDSFE
     AKRAELLADY PDGAEDRDEY AADNVFWVPP TARWSHLQAN AKSPSIGKMI DEAMFAIEKD
     NDNLKGVLPK DYARPSLNAV MLGELIDLIS NIALGAQKGE ARDILGRVYE YFLGQFAGSE
     GKRGGEFYTP RSVVRVMVEM IEPFKGRVYD PCCGSGGMFV QSESFAREHE GRIGDIAVYG
     QESNYTTWRL CKMNLAVRGI DADIKWNSEG SFHKDELRDL KADFILANPP FNISDWGGDR
     LQEDVRWKYG IPPAGNANFA WVQHIVHHLS PTGVAGVVLA NGSMSSTQNN EGAIRQALIE
     GVNGAPGVVD CMVALPGQLF YSTQIPVCLW FLARDKSNGV ARNAKLRDRR GEILFIDARK
     LGHMVDRTRK EFSDADIEKI TRAYHAWRGE ADAGVYEDEP GFCKAATLEE IKGHGYVLTP
     GRYVGAADVE DDEVPFVERF ATLRAKLDDQ FNTASGLTET IRLKLAGLVL DA
//