ID A0A2P2GKA9_9ACTN Unreviewed; 564 AA.
AC A0A2P2GKA9;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Protease {ECO:0000313|EMBL:KKZ71953.1};
GN ORFNames=VO63_21155 {ECO:0000313|EMBL:KKZ71953.1};
OS Streptomyces showdoensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68268 {ECO:0000313|EMBL:KKZ71953.1, ECO:0000313|Proteomes:UP000265325};
RN [1] {ECO:0000313|EMBL:KKZ71953.1, ECO:0000313|Proteomes:UP000265325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15227 {ECO:0000313|EMBL:KKZ71953.1,
RC ECO:0000313|Proteomes:UP000265325};
RA Thapa K.K., Metsa-Ketela M.;
RT "Draft Genome assembly of Streptomyces showdoensis.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKZ71953.1}.
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DR EMBL; LAQS01000032; KKZ71953.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P2GKA9; -.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000265325; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07496; Peptidases_S8_13; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034176; Peptidases_S8_13.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000265325};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 446..564
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 160..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 135
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 196
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 386
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 564 AA; 56979 MW; B31A89F0C2D6257A CRC64;
MAALPSAPVD KVIVTYKSSS AEAGSNTAAK TDAADKAAET GEKLSFERRL AGGAALVDLG
GSATKQDVAE VMAAFRADPQ VASVEPDIRA YAMAVTPNDT DYAKQWDLFE PTGGMNVPTA
WDKTTGSGVT VAVIDTGYAA HSDLATNVVS GYDFISTSAD ARDGNGRDAD SKDEGDWNAT
DGECGTGSKA SNSSWHGTHV AGTIAAVTNN TKGIAGIAYN AKIQPVRVLG KCGGSSSDIA
DAITWASGGT VPGVPANPTP AKVINMSLGG ASATCPSVYQ NAINGAVSRG TTVVVAAGNS
NADASGFTPA NCSGVITVAS TSREGNRSFY SNYGSIVDVA APGGETRRAT DTPGTVTTPE
NGIYSTLNSG TTVQSAENYK PYQGTSMAAP HIAGLAALLK SAKSTLTPAQ IESAIKTNAR
PLPGTCTGGC GTGIADAAKT VDAVTTTPPA GTVFTNATDV TIADNATVSS SIAVTGRTGN
APAALKVDVD IKHTWRGDLV IDLVAPDGTV RNLKASSSSD SADNVLATYT VDASSEVANG
TWKLQVRDVA SGDTGYIDSW SLTF
//
