ID   A0A2P2GV21_9ACTN        Unreviewed;       432 AA.
AC   A0A2P2GV21;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H5 {ECO:0000313|EMBL:KKZ75342.1};
GN   ORFNames=VO63_02540 {ECO:0000313|EMBL:KKZ75342.1};
OS   Streptomyces showdoensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68268 {ECO:0000313|EMBL:KKZ75342.1, ECO:0000313|Proteomes:UP000265325};
RN   [1] {ECO:0000313|EMBL:KKZ75342.1, ECO:0000313|Proteomes:UP000265325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15227 {ECO:0000313|EMBL:KKZ75342.1,
RC   ECO:0000313|Proteomes:UP000265325};
RA   Thapa K.K., Metsa-Ketela M.;
RT   "Draft Genome assembly of Streptomyces showdoensis.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKZ75342.1}.
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DR   EMBL; LAQS01000003; KKZ75342.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P2GV21; -.
DR   OrthoDB; 4318225at2; -.
DR   Proteomes; UP000265325; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265325};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..432
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015141246"
FT   TRANSMEM        400..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..234
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   432 AA;  45623 MW;  AF03C0D40C0F4BE1 CRC64;
     MITRKRLATG ACGALLAALA VGLLPTSAAA DDGPTATDSP KESPKVELVL DVSGSMRARD
     IDGQSRMSAA KQAFNEVLDA VPEEVRLGIR TLGADYPGQD RQRGCKDTRQ LYPVGPLDRT
     EAKTAVATLA PTGWTPIGPA LLGAAEDLKG GEATKRIVLI TDGEDTCAPL DPCVVARDIA
     AKGIHLVIDT LGLVPDAKTR RQLMCIAEAT GGTYTSVHRT EELSGRVRQL VDRAADPVVT
     PIAAQGAERC ADAPTLKPGL YTDRQVIGRH RWYRVDVLPG QELRASVSVS ADRAVNDDYG
     VLLRAVTVHG REIVRGSEAG DGRTDVVSTG LRYPKAELDE GFGDGDAKPA AEVVCLQVSN
     SFSAPPSVKT TPGMPVELAI DVVDGPASSS DVASFGLGRG WWLLGALALA GFLGGLLWGW
     LSRWRVAVWR TH
//