ID   A0A2P4UBW4_9ACTN        Unreviewed;       929 AA.
AC   A0A2P4UBW4;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Transcriptional regulatory protein UhpA {ECO:0000313|EMBL:POM22526.1};
GN   Name=uhpA_2 {ECO:0000313|EMBL:POM22526.1};
GN   ORFNames=BTM25_54760 {ECO:0000313|EMBL:POM22526.1};
OS   Actinomadura rubteroloni.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=1926885 {ECO:0000313|EMBL:POM22526.1, ECO:0000313|Proteomes:UP000242367};
RN   [1] {ECO:0000313|EMBL:POM22526.1, ECO:0000313|Proteomes:UP000242367}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5-2 {ECO:0000313|EMBL:POM22526.1,
RC   ECO:0000313|Proteomes:UP000242367};
RX   PubMed=28463423; DOI=10.1002/chem.201701005;
RA   Guo H., Benndorf R., Leichnitz D., Klassen J.L., Vollmers J., Gorls H.,
RA   Steinacker M., Weigel C., Dahse H.M., Kaster A.K., de Beer Z.W.,
RA   Poulsen M., Beemelmanns C.;
RT   "Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F:
RT   Rare Tropolone Alkaloids from Actinomadura sp. 5-2.";
RL   Chemistry 23:9338-9345(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POM22526.1}.
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DR   EMBL; MTBP01000005; POM22526.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P4UBW4; -.
DR   Proteomes; UP000242367; Unassembled WGS sequence.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242367}.
FT   DOMAIN          864..929
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   929 AA;  99019 MW;  556659ACF422FFD4 CRC64;
     MSAALDGLGG SRAQVVELVG DPGMGKTWLL NETAREAAAR GIRVMHDRYT ESRRNALLRT
     LAMALCPEGA PDLVDSLPRG TRDRLIELMG SPWVWGDPGQ HADRHMLYQT MRILLSACSS
     DGLVVLLDDA HWADGGSVEM VEQLVHRPLA APLLMVVAQR PRQASARLRG ALAHGVEIGT
     VRRVELAPLS AEQSAEVLGA SAADAALREL HNESRGIPLY LRALAGERER GRVPEQQATL
     ILDEIGHLDA CEFRVISAAA VLGDESDLDT LTAVADIGLE GTRTALGGLT RRDLLRPVGD
     SSYFTFRHPL VRRLVYDRTE RSWHAAAHRR AAGFLAGRGA SATQLAVHVE RCVSGPDPAD
     LDVLCRAADD ALMSDPETAI RLLRTALRFQ GEGRARPATM LRLAEALGVA GRLRESRDLL
     DETLRLIPAD DDHDVRVRTT AFYTLVVCLL GDYAKARSLL EGELTKLPAD VPPRETTALI
     IAHGAIGAVD GVAPTCDQVK LARRLAALHE DRVAEVGALA LGALCDAFQD DAEGAAHYAA
     AAAALTDRLS DADLAAHPEY LGILGWAEAL IGRAEDARRH LRRGTTIART RCHVHLLPVL
     LVGEAALRMN GGRPGEARRL AAEAREVAER VNADHVRGMA LVLESLAAAW TGRAAEAVEL
     GEEAERVLHE RRFHWSAAAP VALAVAARLS GDPRRCMMLL LDAGGGGLHA LPRGLRASAL
     ETLTAAALDI RRTGAAPVPA ALTGEWAEQA RDVADAADAA CRPGPRGHAL AALAHARRAD
     GDPGGALELY REAVRLFAAA GATHAQALAV TAEAACLAAL GRRAEAEGAV LLAAELARRS
     GAAAVQDQLR RLDLDGVPAG APVPEDRLAV LTVREREIAE RAGLGRKTRE IAEELSLSPR
     TVDVHLTRIY RKLHITSRAA LARMMAGVG
//