ID   A0A2P4UEG7_9ACTN        Unreviewed;       312 AA.
AC   A0A2P4UEG7;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase {ECO:0000313|EMBL:POM23450.1};
DE            EC=3.6.1.40 {ECO:0000313|EMBL:POM23450.1};
GN   Name=gppA_2 {ECO:0000313|EMBL:POM23450.1};
GN   ORFNames=BTM25_46030 {ECO:0000313|EMBL:POM23450.1};
OS   Actinomadura rubteroloni.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=1926885 {ECO:0000313|EMBL:POM23450.1, ECO:0000313|Proteomes:UP000242367};
RN   [1] {ECO:0000313|EMBL:POM23450.1, ECO:0000313|Proteomes:UP000242367}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5-2 {ECO:0000313|EMBL:POM23450.1,
RC   ECO:0000313|Proteomes:UP000242367};
RX   PubMed=28463423; DOI=10.1002/chem.201701005;
RA   Guo H., Benndorf R., Leichnitz D., Klassen J.L., Vollmers J., Gorls H.,
RA   Steinacker M., Weigel C., Dahse H.M., Kaster A.K., de Beer Z.W.,
RA   Poulsen M., Beemelmanns C.;
RT   "Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F:
RT   Rare Tropolone Alkaloids from Actinomadura sp. 5-2.";
RL   Chemistry 23:9338-9345(2017).
CC   -!- SIMILARITY: Belongs to the GppA/Ppx family.
CC       {ECO:0000256|ARBA:ARBA00007125}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POM23450.1}.
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DR   EMBL; MTBP01000003; POM23450.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P4UEG7; -.
DR   Proteomes; UP000242367; Unassembled WGS sequence.
DR   GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR003695; Ppx_GppA_N.
DR   PANTHER; PTHR30005; EXOPOLYPHOSPHATASE; 1.
DR   PANTHER; PTHR30005:SF0; RETROGRADE REGULATION PROTEIN 2; 1.
DR   Pfam; PF02541; Ppx-GppA; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:POM23450.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242367}.
FT   DOMAIN          19..305
FT                   /note="Ppx/GppA phosphatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02541"
SQ   SEQUENCE   312 AA;  33685 MW;  6D3B8BBA909FED3D CRC64;
     MRLGVLDVGS NTVHLLVVDA HRGARPLPAF SHKAELSLTA HLDEGDRLTA EGEDLLCAFV
     GEALQIAEDK GVENVVAFAT SAVREAVNGE EVLERVRAAA GVDIRVLSGP DEARRTFLAV
     RRWFGWSSGR LLVVDIGGGS LEIATGLDEE PDVAISLPLG AGRLTRDRLS DDPPPPEEIR
     ALRKHVRAEI ARRVGEIVRF GRPDHAVATS KTFKQLARIA GAAPSSEGPF VRRVLRHQDL
     TDWAAKLAEL APEERAALPG VSERRAAQLP AGAIVADAAM DLLELPELEI CPWALREGVI
     LQRLDTLDTP RP
//