ID A0A2P4UII8_9ACTN Unreviewed; 368 AA.
AC A0A2P4UII8;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Trifunctional NAD biosynthesis/regulator protein NadR {ECO:0000313|EMBL:POM24864.1};
GN Name=nadR {ECO:0000313|EMBL:POM24864.1};
GN ORFNames=BTM25_35020 {ECO:0000313|EMBL:POM24864.1};
OS Actinomadura rubteroloni.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1926885 {ECO:0000313|EMBL:POM24864.1, ECO:0000313|Proteomes:UP000242367};
RN [1] {ECO:0000313|EMBL:POM24864.1, ECO:0000313|Proteomes:UP000242367}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-2 {ECO:0000313|EMBL:POM24864.1,
RC ECO:0000313|Proteomes:UP000242367};
RX PubMed=28463423; DOI=10.1002/chem.201701005;
RA Guo H., Benndorf R., Leichnitz D., Klassen J.L., Vollmers J., Gorls H.,
RA Steinacker M., Weigel C., Dahse H.M., Kaster A.K., de Beer Z.W.,
RA Poulsen M., Beemelmanns C.;
RT "Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F:
RT Rare Tropolone Alkaloids from Actinomadura sp. 5-2.";
RL Chemistry 23:9338-9345(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POM24864.1}.
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DR EMBL; MTBP01000002; POM24864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P4UII8; -.
DR Proteomes; UP000242367; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR038727; NadR/Ttd14_AAA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR37512:SF1; AAA_28 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37512; TRIFUNCTIONAL NAD BIOSYNTHESIS/REGULATOR PROTEIN NADR; 1.
DR Pfam; PF13521; AAA_28; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242367}.
FT DOMAIN 167..346
FT /note="NadR/Ttd14 AAA"
FT /evidence="ECO:0000259|Pfam:PF13521"
SQ SEQUENCE 368 AA; 39983 MW; 127F4D4324311B3C CRC64;
MTRYAHGLVI GKFYPPHAGH HHLIDRAAEQ CARVSVLVCA STAESVPLAL RTAWLREQHP
QPQVDVVPVM DDVEVDYASD AIWTAHVDAF RSGLAALAGP DAPRPPVDAV FSSEEYGPEL
ARRFGAAHVP VDPPRVRFPV SGTAVRRDPV AAWEWLAPPV RAYLARRVVV VGAESTGSTT
LARALAAHYA ARGGPWAATR WVPEYGRTFT EEKLAAARRA SGNPGLWLDD LAWESAEFTT
IAERHLALED AAARAGSPLL VCDTDAFATA LWHERYLGAA APDVERLHAR APHHLWILTA
AAGVPFEQDG WRDGADIRAW MDGRFRDELS RRGMRHVVVT GTPGERLAAA VAAVDALLAE
GWTFSPPL
//
