ID A0A2P4UKQ8_9ACTN Unreviewed; 403 AA.
AC A0A2P4UKQ8;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Acetoin utilization protein AcuC {ECO:0000256|ARBA:ARBA00020218};
GN Name=acuC {ECO:0000313|EMBL:POM25569.1};
GN ORFNames=BTM25_42170 {ECO:0000313|EMBL:POM25569.1};
OS Actinomadura rubteroloni.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1926885 {ECO:0000313|EMBL:POM25569.1, ECO:0000313|Proteomes:UP000242367};
RN [1] {ECO:0000313|EMBL:POM25569.1, ECO:0000313|Proteomes:UP000242367}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-2 {ECO:0000313|EMBL:POM25569.1,
RC ECO:0000313|Proteomes:UP000242367};
RX PubMed=28463423; DOI=10.1002/chem.201701005;
RA Guo H., Benndorf R., Leichnitz D., Klassen J.L., Vollmers J., Gorls H.,
RA Steinacker M., Weigel C., Dahse H.M., Kaster A.K., de Beer Z.W.,
RA Poulsen M., Beemelmanns C.;
RT "Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F:
RT Rare Tropolone Alkaloids from Actinomadura sp. 5-2.";
RL Chemistry 23:9338-9345(2017).
CC -!- PATHWAY: Ketone degradation; acetoin degradation.
CC {ECO:0000256|ARBA:ARBA00005101}.
CC -!- SIMILARITY: Belongs to the histone deacetylase family.
CC {ECO:0000256|ARBA:ARBA00005947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POM25569.1}.
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DR EMBL; MTBP01000002; POM25569.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P4UKQ8; -.
DR UniPathway; UPA00040; -.
DR Proteomes; UP000242367; Unassembled WGS sequence.
DR GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09994; HDAC_AcuC_like; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR003085; AcuC.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01272; ACUCPROTEIN.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Acetoin catabolism {ECO:0000256|ARBA:ARBA00022627};
KW Reference proteome {ECO:0000313|Proteomes:UP000242367}.
FT DOMAIN 32..327
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 403 AA; 42779 MW; 94E142AA6F7C8293 CRC64;
MSSLPPEPST EGCGLRVLWD DRLTSYDFGP GHPMNPVRVE LTVALARALG VLDGPDVTVT
GFDAADDALL RLVHEEAYIA AVRHAGATGL AEERYGIGTE DNPVFLGMHE ASALVAGASV
AAARAVWTGE ARHAVNVSGG LHHALAGSAS GFCVYNDPAI AIAWLLENGA ERVAYVDIDV
HHGDGVQDAF YNDPRVLTIS LHESPRSLFP GTGFPTETGG PDAIGSAVNI ALPPGTSDGP
WLRAFDAVVP QALRAFRPQV LVTQHGADAH ALDPLAHLLL TVDGQRTAHA ALHRLAHEVA
DGRWIATGGG GYELVQVVPR AWTHLLAEAS GRPVAPGTQT PDDWRELVRA RTDEIAPRRM
TDGRTVEFRP FDSGYDPANP VDQAIVATRR AVFPDLGLDP LEI
//
