ID A0A2P4UNL4_9ACTN Unreviewed; 416 AA.
AC A0A2P4UNL4;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Macrolide export ATP-binding/permease protein MacB {ECO:0000313|EMBL:POM26643.1};
DE EC=3.6.3.- {ECO:0000313|EMBL:POM26643.1};
GN Name=macB_3 {ECO:0000313|EMBL:POM26643.1};
GN ORFNames=BTM25_10460 {ECO:0000313|EMBL:POM26643.1};
OS Actinomadura rubteroloni.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1926885 {ECO:0000313|EMBL:POM26643.1, ECO:0000313|Proteomes:UP000242367};
RN [1] {ECO:0000313|EMBL:POM26643.1, ECO:0000313|Proteomes:UP000242367}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-2 {ECO:0000313|EMBL:POM26643.1,
RC ECO:0000313|Proteomes:UP000242367};
RX PubMed=28463423; DOI=10.1002/chem.201701005;
RA Guo H., Benndorf R., Leichnitz D., Klassen J.L., Vollmers J., Gorls H.,
RA Steinacker M., Weigel C., Dahse H.M., Kaster A.K., de Beer Z.W.,
RA Poulsen M., Beemelmanns C.;
RT "Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F:
RT Rare Tropolone Alkaloids from Actinomadura sp. 5-2.";
RL Chemistry 23:9338-9345(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC {ECO:0000256|ARBA:ARBA00038076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POM26643.1}.
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DR EMBL; MTBP01000001; POM26643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P4UNL4; -.
DR Proteomes; UP000242367; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR025857; MacB_PCD.
DR PANTHER; PTHR30572:SF4; MACROLIDE EXPORT ATP-BINDING_PERMEASE PROTEIN MACB; 1.
DR PANTHER; PTHR30572; MEMBRANE COMPONENT OF TRANSPORTER-RELATED; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:POM26643.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:POM26643.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000313|EMBL:POM26643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242367};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..258
FT /note="MacB-like periplasmic core"
FT /evidence="ECO:0000259|Pfam:PF12704"
FT DOMAIN 298..407
FT /note="ABC3 transporter permease protein"
FT /evidence="ECO:0000259|Pfam:PF02687"
FT REGION 64..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 41288 MW; EE7AE74B01462A90 CRC64;
MTPAEILRFA LRGLAANKLR SALTTLGILI GVASVIVLVA VGNGSSEAVK KSIQRLGADA
LTVTPSTTGS GRGGLFGRGA AQQQPSGPRT QAHDLTVADA AALGSSGQAP SVRSASPVVT
SQSVTASYAG TSATIGQFVG TTPTYFPAAN KTLASGSLFS ATDAKAVVLG STTASDLFGA
VSPIGKKIDV GGIRFTVVGV LKATGSSSSS FSDPDSIAVA PLAAVQQSLT GYGGLDQIIV
QATGSDAVDA AQAEITALLA QRHGAATSGT ADFTVSSQAS VQSAVSDSTR TFTVLLGAVA
AISLLVGGIG ITNIMLVTVT ERTREIGIRK AIGAPRGAIL AQFVVEATVL SLIGGLLGVA
VGVGGTLFRI AGVQPVLVPS SIALALAVSV AIGLFFGGFP AGRAARLRPI EALRHE
//
