ID A0A2P4ZDG7_9HYPO Unreviewed; 3964 AA.
AC A0A2P4ZDG7;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Beta-ketoacyl synthase domain-containing protein {ECO:0000313|EMBL:PON22311.1};
GN ORFNames=TGAM01_v208794 {ECO:0000313|EMBL:PON22311.1};
OS Trichoderma gamsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=398673 {ECO:0000313|EMBL:PON22311.1, ECO:0000313|Proteomes:UP000054821};
RN [1] {ECO:0000313|EMBL:PON22311.1, ECO:0000313|Proteomes:UP000054821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6085 {ECO:0000313|EMBL:PON22311.1,
RC ECO:0000313|Proteomes:UP000054821};
RX PubMed=26893428;
RA Baroncelli R., Zapparata A., Piaggeschi G., Sarrocco S., Vannacci G.;
RT "Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising
RT Biocontrol Agent of Fusarium Head Blight on Wheat.";
RL Genome Announc. 4:e01747-15(2016).
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON22311.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPDN02000039; PON22311.1; -; Genomic_DNA.
DR RefSeq; XP_018666266.1; XM_018800801.1.
DR STRING; 398673.A0A2P4ZDG7; -.
DR GeneID; 29980884; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000054821; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054821};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..449
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2381..2459
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3523..3602
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2478..2534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2478..2528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3964 AA; 437535 MW; 5CC82B5D009E6F67 CRC64;
MALPTFKTEP IAIVGSSCRF PGGANSPSKL WQLLKNPKDV LVKIPPSRFN PDGFYNTNGE
HHGSTNVLHS YLLEEDHREF DHNFFNIHPK EAESMDPQQR MLLETVYECV EAAGYSIQGL
KGSQTAIFVG QMTQDYSDLM LRDVDSAPQY AATGISRAIL SNRVSYFFDW KGPSSTIDTA
CSSSLVALHH AVQTLRSGES SLAVAAGVNL ILGPDPYILE SKLHMLSPTG RSRMWDADAD
GYARGEGFAS ILLKTLSQAI KDGDHIECLI RETGVNQDGR TSGITMPSSI SQTALIKSTY
TRAGLDFNKK TDRCQYFEAH GTGTMAGDPI EARAVRDAFF GADEEEDSAN AAELDEPLYV
GSVKTVIGHL EGTAGLAGLL KASLAVQHGV IPPNMLFNKL NPAISPFYTH LCVPTQAKPW
PKLPPGVPRR ASVNSFGFGG TNAHAILEHW PSRGYDRALQ IPCGPFTLSA NTEKAVRARA
QTLSAALESG QVTDLSDMAW TLQTRRTQFP HRIYISASNQ EELVKKLNDV ASQSASTTTR
AIHVTEDLPA RILGVYTGQG AQWPSMGRRL YEKSKRFKQT IDDLEKALSN LAIPPSWSLS
GELVASAEDS RIHEAAISQP LCTAIQIALV DLLYASGITF SAVVGHSSGE ISAAYAAGHL
KAADAVAIAY YRGVFAHLAG GPDGRKGKMM AVGMSFDQAL FFCKEAQFAG RIQVAASNSR
SSVTLSGDED AIEEAKQVLD EQQTFARVLK VEKAYHSHHM QRCAQHYLES LQKLDIQIRA
DQLKCKWYSS VYGSNGRSIE DTDAYKASYW VDNMVKPVLF SQAIDRAVVE EHCHDIVMEV
GPHPALKAPV LETLKNLTGL DLPYSGVLKR GQDDMESFSD ALGFIWSNFH TPTPIVDFAG
FRRACLGDEA GESITLKGIP PYPWDHDTKL WKESRKSRNY RSRKNPMHEL LGYATTHGNN
SEVIWRNVMK IKEMEWLRGH IFQGQVLFPA AGYVSMAYEA SIRLAAGETQ VRLVELEDLV
IHRAITLEDE SSGTEVTFTI RVKSQTSDQI TAEYSCYSCK VDGGSELPDS TNFTGRAIIH
LGTPRLDSLP SREAPKLPMK PVSVNRLYSY MEEVGLRYTG EFVVEGVERR LNTSTVKLQR
LDNSKTKLHP ATLDAAFHGI FTALAFPGDG QLWTPYLPTN IRRVRINPAA LDAPVSSSDI
SDLVADCYLT NANSKTICGD VNVSSSTTGI TQIQLQSLTC SSFTKATPQN DRKLFAKTVW
MRDISSGIEP DKVQYLSEEE VDYGDICERL AYFYLRKLRK EISPEEIPRM DEHFQIQIDW
ILNYLLPKIE AGNHPRIKKE WVTDTEEDAH KWMAKYSGKV ELQMISALGE VQPSILRGQL
PALQVMMQKD MLTRLYAEAV PFRQTYSHLI TVTSQLAHRY PRMRVLEIGA GTGGASIHML
KGLAGHCHSY TYTDISAGFF EAAQERFREY SSLMEWAVLD IERDPCEQGF EKHSFDVIMS
SNALHATKSL AQTLTHCRAL LKPGGFMILN EVTNDGVLPQ FISSHLPGWW LGRGDGRLYH
PTVDESRWHQ ELLATGFSSV DAAYRDYHDP KRYLASLIVS QAVDDRISLL RSPLSSKENI
PRVKHLFIVG GESDEVQNLV RKVEPLFRHI ALTVTLVTTL EEVGEVIPGS AVLILSELDK
PTFEQITPQK FRGIQLILQD AKYVLWVTQK CRDDNPMSNM VVGLGRSVLH ELPDLRLQFL
DINAAQAGAV EPSLFVETML RTICLDSPEF DGILWHEEWE LSINGDGLYI PRIVPVEHMN
DRLNSTRRDI VSPVSLGEVC IELGRSNGSR SLQQVRSKME ATTSTDTVQI RVHYSSLLPI
QTRDNLLLHL CIGSIGQSSQ MALVFSPHAR SIVDVPKVEV LLLQQQFATS SDAERLMATI
IAESIVQSSR GNIWIHDSDI PLAKVISTVA GMRGLDVFFS TSSEANSQSN FDQAFIHPYA
TERDARNIIP ADIQSFVNLG KFNSVLHRIV LSSQRINQLA IYDEHSIHGR FTKKDMADIA
IRHILSLSDD LGHHQSAIPL DQVMDMPSLP ETPTAMISWH SSDSMDLKIN PVDPNDLFSA
NKTYLLVGLA SELGLSLCDW MVTHGARNIV VTSRNPGRVD AEVLKHLRRK GAKINIFALD
ISDKEELLKI YKEVCDTMPP IAGVANAAMV LNDKLFNNMT LADFEVALKP KVTGTQNLDD
IFYSTPLDFF ICFSSLTCVM GNGGQSNYAA ANMYMHSLVR QRKKRGVSAS IIDIAFLLGV
GFVARNLEQY EDHLKKVGYM RMSEPEFHTV FAEAIVAGKS TSDEDPEIII GIGQAPNAPW
YTNPRFATYV PHENTTENSD REQVQSSDSV QGRLAAAGSG KDALTVLQIV CAEKLAMILQ
VHSDSIDHAA PLLKLGIDSL VAVEIRSWFL KEVNVDMPVL KILSGASLAD ICQDALVMLP
PTLVSSANED LISSNVAPKA QNHQAPTVAA TSKETQLSIP PTTVASNSDR EGDSSTELST
VSPKPSSVSE ETFEDRSYVR MGEMTPGQSR LYFLHVYLED KTTYNVTMSG KLSGPLNIDN
FSNALDALSE KHEGLRTSFY LDSASGKAMQ GVNRRSSIIL EHANIPGDSS VKIQESLDDM
KRFKFDLNRG KWMKIRILSL SPSDHRIIFT FHHIALDGVG WSIFLKDLND AYAGKGVRTP
RQQAIDLSQK MQREAASGTL AEDLQFWKDT YDSIPEPMPL FPTSKVQHRQ LLKSYDTETL
DLILQRPLVH QIKQASADLQ LTSFHFYLSA IAAFVSKCLN IGDFAVGILD ANRTSAADMT
TIGYFTNLLP LHFKTNASES FADLAVRTRD ITLAALSHSR VDFDQILDTL NIFRSGDQNP
LFQIAVNYRL GGSRTMPLGE CEIQWTSTHD ARNPYDLIID ISEIAEGTII SFTTQSYLYS
TCDTDMLLKW YTHTLKEFAA DTSKLALDCT LAPSTDIQRA ISVGRGSRID IEWDAPTLAH
RIIEMAETSP TSMAIKDGYS RQLTYSNMMR RVQQFAEHLS NLSPGSYVGV LLEPAADTIC
SLVAIMILGL VYVPLDLRNP EGRLAAIIAD CKHAAIICQN ETLGLAQKLT LTVGNTLITL
LNTSDVPTAT TRGNSPTHCL AQPHAPGFAI YTSGSTGTPK GVLLTHHCVL NQIWGISKMF
EIKKENVLQQ SSFGFDLSLE QVFIALANGG TLIVASKEAR GNALEIANLI LSENITYTVF
VPSEYLHLLH YTSNILKACS SWKFAFSGGE KVTAQLRRGF KKLDLPNLRL INLYGPAEAS
LSCTRYEIPY RTDKTTTASP AGFVMPNYTV IVVDQIGSPL PFGFPGEICI AGAGNSIGYV
NQPQETASKF TPDRVSPVED INRGWNTLYH TGDKGRMLDN GLLEFIGRLD GDSQVKIRGM
RIEMDEIAKT IVDASQGVVD DASVSLRGSD LLVAYVVFSD GFAGDTNLAV ERIRNDLPLP
SYMCPAHIIA IDEIPRNPNG KKDKSKIDAL PIPDALEVKT QTGDLSDFEK AVVAVWRDVL
PNTMKLSQFG SETNFFFVGG NSLLLLKLQA ELEMAFGRNL TLSELFQAST IREMAAKIQA
VSDKPLRQHI DWNKEIRSLC DGLSRSAFTK PVNVSSSKSG LSVVLTGATG FLGRNILKCL
VNDDRVSEVH CIAIRPDVNG LPRHVDVSSP KIIEYSGDLA DHDLGLSPEQ LESIASRANV
IVHNGADVSF MKTYQSLRRS NVLSTRRLAE IAAAVSIPFH FVSTASVAHL YPGEHLSEVP
LEAQADLPAD GQQGYAISKW VSEALLEYLA DNHDLQSCVH RPTSIIGDGA PDTDIIASLH
TYSEILGSVP KLSGVITGNL DFVDVQNVAK EIATQALAST SANQMDPSPK TFYINHCNEE
KVSIPNLKEY MEKAKGKLFS ELELNDWLQK AREAGLNELI CVYLKNMVDK KEPLYLPSLV
KGKV
//
