ID A0A2P4ZMU2_9HYPO Unreviewed; 833 AA.
AC A0A2P4ZMU2;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=TGAM01_v205469 {ECO:0000313|EMBL:PON25584.1};
OS Trichoderma gamsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=398673 {ECO:0000313|EMBL:PON25584.1, ECO:0000313|Proteomes:UP000054821};
RN [1] {ECO:0000313|EMBL:PON25584.1, ECO:0000313|Proteomes:UP000054821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6085 {ECO:0000313|EMBL:PON25584.1,
RC ECO:0000313|Proteomes:UP000054821};
RX PubMed=26893428;
RA Baroncelli R., Zapparata A., Piaggeschi G., Sarrocco S., Vannacci G.;
RT "Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising
RT Biocontrol Agent of Fusarium Head Blight on Wheat.";
RL Genome Announc. 4:e01747-15(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON25584.1}.
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DR EMBL; JPDN02000017; PON25584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P4ZMU2; -.
DR STRING; 398673.A0A2P4ZMU2; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000054821; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000054821};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 174..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 210..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 468..493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 514..541
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 601..663
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 91960 MW; 2593079E2A03E130 CRC64;
MNSHTAAFGA PSPALSRRPS ISSRLSFAVS NAEQGEASAR NAPREGQIEE EIAEIKRYED
FTTIDWVQDA AREQARRSAR RTRTAGVYRL GQPGWRYRLW ESYDAAQGWI VVTIIGAAIG
LNAAFLNIVT EWLSDIKTGH CTTGFYLNEK FCCWGEDNGC EAWHRWTGFG PLNYFIYFIF
ATTFAWVSAT LVKSYAPYAA GSGISEIKCI IAGFVMKGFL GFWTLLIKSI CLPLAIASGL
SVGKEGPSVH YAVCTGNVIS RLFNKYRSNA SKTREILSAC AAAGVAVAFG SPIGGVLFSL
EEMSSYFPLK TMWRSYFCAL VATAVLSAMN PFRTGQLVMF QVKYDRDWHF FEVVFYIIIG
IFGGLYGAFV IKWNLRAQAF RKKYLTKYAI LEATLLAAGT AIIAYPNAFL KIDMTESMEI
LFLECEGAEN YHGLCDKDKR AWNLVSLILA TVLRVFLVII SYGCKVPAGI FVPSMAIGAS
FGRTVGIIVQ AIYEANPTSV FFSACKPDEP CITPGTYAFL GAAAALSGIM HLTLTVVVIM
FELTGALTYI LPTMIVVGVT KLVSEMFGKG GIADRMIWFN GFPFIDSKED HNYGVPVSQV
MRSSVVSLSV NGLTVADVEE LLAEDKYQGF PIVLDSTSKT LVGYIGRTEL RYAIDRAKRE
RPVSQDAKCF FSPHPTQAPA ITPVTPAFRS DTAASSPLDF SRYIDATPVT AHPRLPLETV
MELFQKIGPR VILIEYHGKL SGLVTVKDCL KYQFKVEAAE NPKDDQHVVE GQEHLWSALR
RVGFWVSNSV STVSRGHVRL SGQFDDERAR GRRGNILDGD EEGVDEGVEL ERR
//
