ID A0A2P5AJ72_PARAD Unreviewed; 2021 AA.
AC A0A2P5AJ72;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=PanWU01x14_327260 {ECO:0000313|EMBL:PON36588.1};
OS Parasponia andersonii (Sponia andersonii).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Parasponia.
OX NCBI_TaxID=3476 {ECO:0000313|EMBL:PON36588.1, ECO:0000313|Proteomes:UP000237105};
RN [1] {ECO:0000313|Proteomes:UP000237105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. WU1-14 {ECO:0000313|Proteomes:UP000237105};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON36588.1}.
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DR EMBL; JXTB01000562; PON36588.1; -; Genomic_DNA.
DR STRING; 3476.A0A2P5AJ72; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000237105; Unassembled WGS sequence.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000237105};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1158..1281
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 1426..1874
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1920..1993
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT REGION 777..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2021 AA; 225538 MW; D9632952B68F973E CRC64;
MADSSVFSLR IVSVDYYMAP PIPDLDISYS SFHGGKVNEV PVIRIFGSTP AGQKTCLHIH
RVLPYLYVPC ADLPIHPQKE VDAYRHEISL ALEKALKLKS KACSKRQYVH GCSLVRARRF
YGYHSSEELF VKIYLYYPHD VSRAANLLLG GGVLDKSLQP HEAHIPFILQ FLVDYNLYGM
GHVHLSKMKF RHPVPDVFSP RKSVYTDQTK WSMDPLTCMR PDSQADISGS SSFDSPVWVS
STVPADWMWH SPCEFAASSN LGIIKRQSLC QLEGDATVDE IHNQHSKMYT SLSQTRSDVK
MVQSLVPIWE EEYERTGLHE VAIPSDPGKP PPEDVLKTLS LGPEFKNILN ALHSVAESSL
SLTPLDNKDV RSVRLTTTST NERNLAGLGH VSDSDGVDVE PSKCHKERGL IQSLSSQEAD
GVIPSIKRDA NVKLSSTDEL PPSQIIETLY RKGADEEALG LLKWLATSQA ADDINSDDEL
LRETILSPLF PATTIEEVLE KASMDYESES QKECQDILDS VDEFVDPKDL PECNHSSRIS
SERVIPQVDG AGDDMFVTSC GSTEEFSEIE SKSKFDEACE HEILAKDALI GKRVLEDAHS
SFTHKHKRKK LFWGSLPFSI NQKSKTEKDF VSSCGGTQVP FTESSLSEHK MGKHEYSSMK
NVNNNVCDIK ETTPLVECSV RDLMRRKRHH RIKPVECNSL RVEKVSLDEK EKEDTNIIPR
QLDYQMFQID DPSRRPLDSL NFCPSLVVSE SIGHEFYDVK TIDDSFLGVN SSDDGNFGSH
KGNSNDGSGT VTRSGNLLGR GHSDVHISSA LSKPRNPDSE AAIAHYENDQ ESDIQLLKPD
TEENTFAAAS SSFQTTVGHE ELGVKSGTEG QPSGEWAHEM SSKKPDVRNR NNTNVLNSGQ
SHGVQVSMVY ENDLQDKDLI SMTFCRKPPA TEWIDSSSRK SFSCPIVSYL PCPDKESHDG
TSGKFLDDCL PFFMEDVQEK TKSQNKNMNV SDFTLQKEAA IGVPTHYQND GSRLYLLTPI
ISPPPAENVI RWLSSGTSVE DNTVLAKVSS QIGTSSSLIG SPSSSCDDCN KASPESGSIS
HQKHILAQRS QDNCDNIDTT RDLTCNEETA VMQREGNSEK VKAYSQDISQ ISGPDWRPKP
TPLSQIGFRD PASVGGGQQL TLLSIEVQAA SRGDLRPDPR FDAINIISLA VQNDSDFDIK
VHVLLHCKAE QFQRNLDGIS GCNVLVFFEE THLFDHFIKF VCFLDPDILM GWDVQGGSLG
FLAERASYLG IGLLNSISRI PPESKIAAGD LEIPEKKALD NIVLESALVD SIVLEDIIIE
DEWGRTHASG VHVGGRIVLN VWRLMRGEVK LNMYTIEAVA DAVLRRKIPY ISCKVLTRWF
SSGPGRARYR CIEYVKERAK LNLEIMNQLD MINRTSELAR VFGIDFFSVL SRGSQFRVES
MYLRLAHTQN YLAISPGNHQ VASQPAMECL PLVMEPESGF YADPVVVLDF QSLYPSMIIA
YNLCYSTCLG NIAPSKANTL GVSPFLQDPH ILQDLKDQIL ITPNGVMYVP SKIRKGVLPR
LLEEILSTRI MVKQAIKKLS PSQQVLQRIF NSRQLALKLI ANVTYGYTAA GFSGRMPCAE
LADSIVQCGR RTLEKAISYV NSQDKWKAKV IYGDTDSMFV LLKGRSVEEA YRIGNEIASE
ITAMNPNPVA LKMEKVYHPC FLLTKKRYVG YSYESPKQVE PVFDAKGIET VRRDTCGAVS
KTLEQSLRLF FELQDISEVK AYLLRQWKRI LSGRVSLQDF VFAKEVRLGT YSTRDSSLLP
PSAIVATKAM RSDPRAEPRY GDRVPYVVIH GEPGARLVDM VVDPLELLAV GSPYRLNDLY
YINKQIIPAL QRVFGLVGAD LNKWFLEMPR PVREAISKRP PYAPNPQRTR IDYYYLSKHC
ILCGELVEAS THLCHQCSQN RSAAFTAVVG RTSKLEREMQ HLAAICRHCG GGDWLLESGI
KCISLACPVF YERSKVQKEL QGLAAVAADR GLYPKCMVEW F
//
