ID   A0A2P5AP90_PARAD        Unreviewed;       473 AA.
AC   A0A2P5AP90;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Pseudouridine synthase {ECO:0000313|EMBL:PON38393.1};
GN   ORFNames=PanWU01x14_312730 {ECO:0000313|EMBL:PON38393.1};
OS   Parasponia andersonii (Sponia andersonii).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Parasponia.
OX   NCBI_TaxID=3476 {ECO:0000313|EMBL:PON38393.1, ECO:0000313|Proteomes:UP000237105};
RN   [1] {ECO:0000313|Proteomes:UP000237105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. WU1-14 {ECO:0000313|Proteomes:UP000237105};
RA   Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA   Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA   Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA   Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA   Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA   Smit S., Geurts R.;
RT   "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT   legume Parasponia.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|ARBA:ARBA00000073};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PON38393.1}.
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DR   EMBL; JXTB01000496; PON38393.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P5AP90; -.
DR   STRING; 3476.A0A2P5AP90; -.
DR   OrthoDB; 11448at2759; -.
DR   Proteomes; UP000237105; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF52; RNA PSEUDOURIDINE SYNTHASE 6, CHLOROPLASTIC; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000237105}.
FT   DOMAIN          221..389
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
SQ   SEQUENCE   473 AA;  52708 MW;  F8B8A982F6E8F091 CRC64;
     MGSVSFASIF ANGCRGLTSP ALLVRTFGLT HVSLSDHSNK LAQVAWSTRT PNTRAFACES
     TKANVADVTT ASSVNGYPKY DRLLPCPSHN LPPRVEHLVV TEGGRVQEYI CKALDLPPLF
     VADLIHFGAV FYALVCPQPP PTATPEQLRL FKEFTTPSVL EGRSSIKGKT LREAQKTFRI
     THVEQFVETG TYLRVHVHPK RFPRCYEIDW KSRIIAVADS YVVLDKPAGT SVGGTTDNIE
     ETCATFATRA LGLTTPLRTT HQIDNCTEGC VVLARSKEYC SVFHEKIREK TVKKLYLALA
     AAPLPIGIIT HYMRPINMAP RLVSEDKIEK WHLCKLEIIE CRKVPWPSSI TKEKYCVEDC
     YWPSKDYAYE CKINLLTGRT HQIRAQLAAR GAPILGDSAY MPAALAEITT PGVNPFGKCR
     KNHSSEDDKE MATTEWIALH GKEPSVAIGL QAFQISWDNG QRIYEAGVPW WRS
//