ID   A0A2P5B0Z9_PARAD        Unreviewed;      1129 AA.
AC   A0A2P5B0Z9;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   22-FEB-2023, entry version 15.
DE   SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:PON42490.1};
GN   ORFNames=PanWU01x14_281320 {ECO:0000313|EMBL:PON42490.1};
OS   Parasponia andersonii (Sponia andersonii).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Parasponia.
OX   NCBI_TaxID=3476 {ECO:0000313|EMBL:PON42490.1, ECO:0000313|Proteomes:UP000237105};
RN   [1] {ECO:0000313|Proteomes:UP000237105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. WU1-14 {ECO:0000313|Proteomes:UP000237105};
RA   Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA   Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA   Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA   Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA   Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA   Smit S., Geurts R.;
RT   "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT   legume Parasponia.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PON42490.1}.
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DR   EMBL; JXTB01000391; PON42490.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P5B0Z9; -.
DR   STRING; 3476.A0A2P5B0Z9; -.
DR   OrthoDB; 5484321at2759; -.
DR   Proteomes; UP000237105; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR015205; Tower_dom.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 2.
DR   SMART; SM01341; Tower; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 2.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237105};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          764..805
FT                   /note="Tower"
FT                   /evidence="ECO:0000259|SMART:SM01341"
FT   REGION          156..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1129 AA;  125262 MW;  D7F41EA95534FCFF CRC64;
     MSTWKIFSGA GNNYRWEATS RDIKTRPEVG PRDIGAQSHV QVHNSSSRLP SMADLLLQGC
     SKLLEDSDEG FDKTPMFKTG LGRTVPVKQS SIAKALSVLG QDDSTDTGQV QARNSECDFS
     KSLFQTGSGK MVNISSDGLA RAKTLLRLVE DNDPGNFQGF QGSRKLSNTD SPSGWQNVSH
     LETREVANGY GNMDGDSVLS SSSSCRTDLG QAVLRNEAKP HLTPSRMYNS VTKVPPVRFQ
     TAGGRSISVS SDALQRARSL LGDPELGTFL DIGDAVNSDF SLSKNRRLVD TLVNEENDPQ
     TTLTHQKMAM SNFMPKSFVS PLRSFSKQMQ SSVNSESIDS GTNLIKQFDA VSHDSVCKLN
     RNLTCQQEPL RNGLCSTNTV VDNSSANSIG LRKNLVGKSP GRQLVDISNT VGTASANDRQ
     ATNEKRRILR TSKSPFKRPR SSKFSTPMKS NAALAPNGLS TFYSEHSCSK GRVSSRYPFQ
     KKRLYVREYF GEPPEHNLLT SSSDQFRRIR ADNAENFTFP DDSGVRCIGA EVFFHMLIRS
     GALEQYASKE WVKNHYKWII WKLGCYERCY PTKSSGKILT ISNVLEELKY RYEREVNHGH
     RSAIKRILEG DASPTSMMVL CISAINSNYD PKIEVTSLGL GDAENHTVAA AKVELTDGWY
     SVDALLDVML LKQLNAGKLF NGQKLRIWGA GLCGWVGPVS PLEVPRTANL GLHINGTYRA
     QWADRLGFCK GLGTPLAFKC IKTNGGQVPL TLFGITRIYP VLYKERLHNG SSIVRSERME
     NKVVQSYNRR RSIIVESIVS DFQRGIKHSH AYNDTESEEG AKILKVLETA SQPEVLLAEM
     SPDQLSSFAK YQAKMEAIRH SDMEKSIEKA LENAGLGKRE VNPFMRVRVV GLTSRTYQRK
     DSPKEGLITI WNPTEKQQAE LVEGKAYKVA GLLPTNTDAD TIYLQARGST TWQPLSLLEL
     EHFKPFFTPR KSVVLSNLGE VPLSSEFDIA AFVVLVGEVY KGAQQMKQWV FVTDRSISDL
     QSEEFSDCLL AICFCSPYID DDSSIPFNRN LAGSTVGFCN LIKRAKDQVN HLWVAEASEN
     STYFLSFDTP PCSHLKDAAV SAERWGKTSE LITDKLREKV SFIIGDHNG
//