ID   A0A2P5D2E1_PARAD        Unreviewed;      1379 AA.
AC   A0A2P5D2E1;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=TIR-NBS-LRR-like protein {ECO:0000313|EMBL:PON67438.1};
GN   Name=PanTNL4 {ECO:0000313|EMBL:PON67438.1};
GN   ORFNames=PanWU01x14_102410 {ECO:0000313|EMBL:PON67438.1};
OS   Parasponia andersonii (Sponia andersonii).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Parasponia.
OX   NCBI_TaxID=3476 {ECO:0000313|EMBL:PON67438.1, ECO:0000313|Proteomes:UP000237105};
RN   [1] {ECO:0000313|Proteomes:UP000237105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. WU1-14 {ECO:0000313|Proteomes:UP000237105};
RA   Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA   Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA   Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA   Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA   Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA   Smit S., Geurts R.;
RT   "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT   legume Parasponia.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PON67438.1}.
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DR   EMBL; JXTB01000071; PON67438.1; -; Genomic_DNA.
DR   OrthoDB; 1211301at2759; -.
DR   Proteomes; UP000237105; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11017:SF595; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS)-RELATED; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237105};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          19..181
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1379 AA;  155386 MW;  2A8716D384CA8578 CRC64;
     MTTIDDPDSS RPAAVAFRLR WDVFLSFRGE DTRHSFVKNL SDSLDKEGVR AFLDDDGLNR
     GDEIAPSLLE AIEDSAAAIV VFSPRYAESR WCLEELAKIC ECPNKLILPV FHLVDPSHVR
     RQVGPFEKHF RVHEKKWPED KVMKWRRAME KVGGIAGLPV FSISEEDQKI QYLVKTVLTK
     LRTTPIGMAE YTVGLDSRVE KLINLLDIKS NGIRVLGLHG PGGVGKTTLA TALYNKLVSR
     FELRSFIPNV RETSANENEG LISLQNKLIN DLSGVKDPSP ITEISFGVSK LEMRVNDKRV
     LVVLDDADDI NQIAALVPER EWFHEGSRII ITARNKGVFP LNRLPTELYE VRELESSESL
     RLFNFHALRK ERPPEAFVKR SEKIVSLTGG LPLALEVFGS FMFGKRRMEE WDDAIQKLAQ
     IRPGNIQNVL KISYDGLNDE QEKSIFLDIA CLFVQMRMKR KEVVDILKGC GFPAETSITS
     LAQKSLIKIL EDNTLWMHDQ VRDMGRQIVM EENISYPGSR SRVWKPSDIK AVLMEEKEEK
     LIQGMVLDFK RKSRVKDPSG EMISLKNFLE NPNFTSALTH LKQIWMEFFQ KGREEEEEKE
     NVISTKPIET MAKLRLLQIN HVNLRGKFNS LPAKLKWLQW KGCPLKALPS DFHAPQLAVL
     DLSESKLESL WGSKNKKIAE NLAILNLREC HSINFIPDLS RHQKLEKITL ENCKGLTQIH
     ESIGNLQTLI YLNLRMCSNL NKLPNDVSGL KRLEKLILSR CSKLKELPTN IGSMESLKKL
     LADETAISSL PDSTFRLRQL EELNLNRCRH LKGLPQCIGN LFSLKELSLD GSGLEELPNS
     IGSLANLEKL SVMWCASLTV LPDSIGKLKS LTDFFILNSP IKELPESVGS LPNLKKLSVG
     IGQFLSRLPS SIGKLDSLVL LQIEETNIID LPDEIGRLKS LETLEIRKCT SLVSLPESIG
     SMTKLTTLII TEAKIKELPV SIGMLENVAK LQLNNCRELF NLPTSIGNLK SLNNLLMEDT
     GVTYLPKSFG RLSSLIFLKM TKKPQGEVVI VSSEEESPND EVLPTSFSDL VKLNELYARY
     CNISGKISDD FEKLSSLEIL DLGYNSFCSL PSSLKGLSIL KKLFLPHCKE LKSLPPLPSS
     LLEIDVANCT VLETVSDLSN LESLQQLNLT SCEKVVDIPG LECLKSLRRL YMSDCNACSS
     EIKKRLAKGS LRNIRNISIP GSNIPSWFSQ EAVTYSERRN HAIKAVIIGI VVSLNHEIQS
     SLRIRTPSVV DIQAKILKLD FPIFTTTLIL LGVPNTNQDQ FHLCRYSVHH PLVSQLKDGY
     QIEVTKRNPP LDPGVELKKS GIYLVYEGDD DYEGDEQSIN ESQRSVSEKL AKFFRTYEV
//