ID A0A2P5D7F0_PARAD Unreviewed; 828 AA.
AC A0A2P5D7F0;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN ORFNames=PanWU01x14_089520 {ECO:0000313|EMBL:PON69229.1};
OS Parasponia andersonii (Sponia andersonii).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Parasponia.
OX NCBI_TaxID=3476 {ECO:0000313|EMBL:PON69229.1, ECO:0000313|Proteomes:UP000237105};
RN [1] {ECO:0000313|Proteomes:UP000237105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. WU1-14 {ECO:0000313|Proteomes:UP000237105};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON69229.1}.
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DR EMBL; JXTB01000057; PON69229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P5D7F0; -.
DR STRING; 3476.A0A2P5D7F0; -.
DR OrthoDB; 147095at2759; -.
DR Proteomes; UP000237105; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000237105}.
FT DOMAIN 346..557
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 828 AA; 91920 MW; A6D66FF3137E66B9 CRC64;
MYGNPGKRSE VEYGSIYGGD LGDVWSKYLS QVELCDEKAA FKLVSLLICF FSSEPGQTLL
SQVKDDNGIF ILSIDFQRFQ KDCDVREFYE LLEDRPKIAL LCMSASVHKV LLNKWEKNQL
EDGTKVNIRL HDYPQSMIAL KNLKAAYIDK LVSVRGSVVK VSTVRPLVMQ MSFDCAKCKT
KILRIFPDGK FSPPTICNLD GCKSKTFIPI RSTAETIDFQ KMRIQELLKP EDHEEGRVPR
TVECELTEDL VDACIPGDVV TVTGIIRVIN NYMDIGGGKS KGKSQGFYYL YLEAISVKNS
KSHSTSEDSV DSNSHARPME LFDLFSFSSR DLEFIVKFSE EHGSDTFRQL LQSICPSIYG
HELVKGDLPA GITLALFGGV RKHSNDNNKV PVRGDIHVII VGDPGLGKSQ LLQAAAAVSP
RGIYVCGNAT TKAGLTVAVV KDPMTSDYGF EAGAMVLADS GLCCIDEFDK MSSEHQALLE
AMEQQCVSIA KAGLVASLSA RTSVLAAANP VGGHYNRAKT VNENLKISSA LLSRFDLVFI
LLDKPDELLD KQLSEHIMSL HTGYGVHAPA AKKLRRGASQ NAGGIDMKVA GGSLISRLRL
DSKRDNDFAP LPLQLLRKYI AYARTFVFPR MSKAAAEILQ KFYLQLRDHA TSADSTPITA
RQLESLVRLA EARARLDLRE EITAQDAIEV VEIMRESLYD KYVDENGFVD FGRSGGMSQQ
KEAKRFLSAL NKQSELQQKD CFSISEIYSL ADRIELRVPD IDAFVDNLNS VGYLLKKGPK
TYQFNHFVVT ESLLATYMHY AVQSLCSDKL HVSGELINII YNSMICNF
//
