ID A0A2P5E5T5_TREOI Unreviewed; 1098 AA.
AC A0A2P5E5T5;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 13-SEP-2023, entry version 21.
DE RecName: Full=methionine S-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00888};
DE EC=2.1.1.12 {ECO:0000256|PROSITE-ProRule:PRU00888};
GN ORFNames=TorRG33x02_233150 {ECO:0000313|EMBL:PON80907.1};
OS Trema orientale (Charcoal tree) (Celtis orientalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Trema.
OX NCBI_TaxID=63057 {ECO:0000313|EMBL:PON80907.1, ECO:0000313|Proteomes:UP000237000};
RN [1] {ECO:0000313|Proteomes:UP000237000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-
CC homocysteine + S-methyl-L-methionine; Xref=Rhea:RHEA:13761,
CC ChEBI:CHEBI:57844, ChEBI:CHEBI:57856, ChEBI:CHEBI:58252,
CC ChEBI:CHEBI:59789; EC=2.1.1.12; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00888};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. {ECO:0000256|PROSITE-ProRule:PRU00888}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON80907.1}.
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DR EMBL; JXTC01000229; PON80907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P5E5T5; -.
DR STRING; 63057.A0A2P5E5T5; -.
DR InParanoid; A0A2P5E5T5; -.
DR OrthoDB; 464292at2759; -.
DR Proteomes; UP000237000; Unassembled WGS sequence.
DR GO; GO:0030732; F:methionine S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR025779; Met_S-MeTrfase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR PANTHER; PTHR47087; METHIONINE S-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR47087:SF1; METHIONINE S-METHYLTRANSFERASE; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51555; SAM_MT12; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00888,
KW ECO:0000313|EMBL:PON80907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000237000};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00888};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00888,
KW ECO:0000313|EMBL:PON80907.1}.
FT DOMAIN 116..169
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
FT DOMAIN 745..1087
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 1098 AA; 121376 MW; 1054680D0FC1F5B6 CRC64;
MVEASVNEFL KQCEQSGDAA YAALRALVER LDDPKTRVQA RIFLSDLQKR FPSKEASDKC
FETYHFRIDD IFLDQYEGYQ GRKKLTTMVI PSIFLPEDWS FTFYEGLNRH PDSIFRDRTV
AELGCGNGWI SIAIAEKWLP SKVYGLDINP RAVKISWLNL YLNALDENGQ PVYDREKKTL
LDRVEFHESD LLAYCRDNGI QLERIVGCIP QILNPNPDAM SKMITENASE EFLYSLSNYC
ALQGFVEDQF GLGLIARAVE EGIAVIKPMG IMIFNMGGRP GQGVCKRLFE RRGFQVTKLW
QTKILQASEL FLIGEASDTD ISALVEIEKN SPHRFEFFMG LSGDQPICAR TAWAYGEAGG
RISHALSVYS CQLRQPNQVK RVFEFLKNGF QEVSNSLDLS FQDDAVADEK IPFLAYLSGI
LKEGSFCTYE PPAGSKRFRN LIAGFMKTYH RIPLSADNVV VFPSRAVAIE NALRLFSPRL
AIVDEHLTRH LPRQWLTSLA LGGTGGSDSV EDVLTVIEAP RQSELMIELI RKLKPQVVVT
GIAQFEVVTS SAFVHLLGIT REIGSRLFLD ISDHFELSSL PSSNGVLKYI AETPLPSHAA
IICGLLRNQV YSDLEVAFVI SEDEAIFKAL SKTVELLEGN TALISQSYYG CLFHELLAFQ
LADRHPPAER ESGKAKSAEM IGFSTSAISV LDSAELSVSE TENSSLIHMD ADQSFLPVPS
PVKAAIFESF ARQNMAESEI DATPSIKQFI KSNYGFPVDA NTEFIYADSS LALFNKLVLC
CIQEGGTLCF PAGSNGNYVA AAKFLKANIV NIPTNFEEGF KLTEKTLSGI LDTVHKPWLY
ISGPTVSPTG LLYNNQEIED LLSICANFGA KVVLDTSFSG LEFDSDGLVG WNLVDCLSKL
KSSNPSFCVS LLGGLSLKML TGPLKFGFLV LNEPALVDAF HSFPGLSKPH STVRYAVKKL
LSLGEQKSGD LWDSIVKEIG NLKNRSKCLK ETLKNCGWDV LEPHGGISMV AKPSAYLNKI
VKLKGSPKDG SIGSAPVYEA ELDDSNIRDV IYRATGLCIN SGLWTGIPGF CRFTIALEQG
EFEQALDCIT KINSIISN
//
