ID   A0A2P5EDZ2_TREOI        Unreviewed;       730 AA.
AC   A0A2P5EDZ2;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE            EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN   ORFNames=TorRG33x02_205470 {ECO:0000313|EMBL:PON83741.1};
OS   Trema orientale (Charcoal tree) (Celtis orientalis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Trema.
OX   NCBI_TaxID=63057 {ECO:0000313|EMBL:PON83741.1, ECO:0000313|Proteomes:UP000237000};
RN   [1] {ECO:0000313|Proteomes:UP000237000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA   Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA   Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA   Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA   Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA   Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA   Smit S., Geurts R.;
RT   "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT   legume Parasponia.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Acts as an
CC       endogenous post-transcriptional gene silencing (PTGS) suppressor.
CC       {ECO:0000256|PIRNR:PIRNR037239}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC       ECO:0000256|PIRNR:PIRNR037239}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PON83741.1}.
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DR   EMBL; JXTC01000174; PON83741.1; -; Genomic_DNA.
DR   STRING; 63057.A0A2P5EDZ2; -.
DR   InParanoid; A0A2P5EDZ2; -.
DR   OrthoDB; 167745at2759; -.
DR   Proteomes; UP000237000; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 3.40.50.12390; -; 2.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR017151; Xrn2/3/4.
DR   PANTHER; PTHR12341:SF79; 5'-3' EXORIBONUCLEASE 4-LIKE ISOFORM X1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF17846; XRN_M; 2.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF037239; Exonuclease_Xrn2; 3.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|PIRNR:PIRNR037239};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237000}.
FT   DOMAIN          1..222
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          293..396
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          405..709
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   REGION          229..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  83487 MW;  D20F49B4CD608831 CRC64;
     MGIPAFYKWV LDRFPRAVMD AHARHGFDXX XXXXCFHPQG LPAPKTYEEV FQSVFKYVDR
     IFSIVKPRKL LYLAIDGVAP RAKMNQQRSR RFRAAKDAAE EAAQKGDVSK SIEKSTSELS
     SKLDSNVITP GTEFMALLSS ALRYYIHLRM NGDPGWQGIK VILSDANVPG EGEHKIMSYI
     RLQRNLPGFD PNTRHCLYGL DADLIMLALA SHEIHFSILR EDVQRSGFKD KSSKSRRNSS
     KSRRGSSKSR GTLEIETLDD YILNQRFQFL HIWILREYLA YAMKIPDPTV IGDLERLIDD
     FVFMCLFVGN DFLPHMPSLE ISEGAIDLLI TIYKKEFVRM GGYLTSSFEV NLERVKHFLE
     AVGSHEGLIL RKRAQEQKEW AIRHRRSSQN KIVGTTSLCQ DSINSSAIEI QAPNNSASST
     TTAVDKIKFG EEGWKVRYYA EKFEAETEDD REKVRKDVVL KYTEGICWVM HYYYGGVSSW
     QWFYPYHYAP FPSDFVGVDE LKIQFTLGEP FKPFDQLMAV LPAASAHALP LFYRKLMTDA
     SSPLLAFYPT DFELDMNGKR FSWQAICKLP FIDETSLLSE VARVENTLTD EERQRNNLGM
     DVIFGHISYP LAMEILSFYR KNIDDLKLTK TEVKWKINPK FSGGTNGYIL ISDKPVQPLQ
     IDSPIDGMEM IADNQVLSVF YECPPLHIHI PRPPEGVQYP GKTIRRKDVK PAPLLWHEKS
     AVVGRLHSLG
//