ID   A0A2P5F968_TREOI        Unreviewed;      1129 AA.
AC   A0A2P5F968;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   28-JUN-2023, entry version 16.
DE   SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:PON94342.1};
GN   ORFNames=TorRG33x02_098160 {ECO:0000313|EMBL:PON94342.1};
OS   Trema orientale (Charcoal tree) (Celtis orientalis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Trema.
OX   NCBI_TaxID=63057 {ECO:0000313|EMBL:PON94342.1, ECO:0000313|Proteomes:UP000237000};
RN   [1] {ECO:0000313|Proteomes:UP000237000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA   Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA   Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA   Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA   Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA   Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA   Smit S., Geurts R.;
RT   "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT   legume Parasponia.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PON94342.1}.
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DR   EMBL; JXTC01000052; PON94342.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P5F968; -.
DR   STRING; 63057.A0A2P5F968; -.
DR   InParanoid; A0A2P5F968; -.
DR   OrthoDB; 5484321at2759; -.
DR   Proteomes; UP000237000; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR015205; Tower_dom.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 2.
DR   SMART; SM01341; Tower; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 2.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237000};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          764..805
FT                   /note="Tower"
FT                   /evidence="ECO:0000259|SMART:SM01341"
SQ   SEQUENCE   1129 AA;  125155 MW;  CFF6CCAA2D1A5123 CRC64;
     MSTWKIFSGA GNNFRWEVIS RDIKTRPEDG PRDIGAQSHV QVHNSSSRLP SMADLLLQGC
     SKLLEDSDEG FDKTPMFKTG LGRTVPVKQS SIAKALSVLG QDDSTDTGQV QARNSECDFS
     KSLFQTGSGK MVNISSDGLA RAKTLLGLIE DNDPGNFQGF QGPRKLSNTN SPSGWQNVSH
     LETREGVSSY GNMDDASVLR SSSSCRTDLG QDILRNEAKP HLTPSRMYNS VTKAPPVKFQ
     TAGGRSISVS SDALQRARSL LGDPELGTFL DIGDAVNSDF SLPKNRRLVD TLVNEENDPQ
     TSLTHQKMAK SNFMPKSFVS PLRSFSKQMQ SSVNSESIDS GTNLIKQFDA VSHDSVCKLN
     SNLTCQQEPF RNGFCSPNTV VDNSSANSIG LRKNLVGKSP GRQLVDISNT VGTASANDRE
     ATNEKRRILR TSKSPFKRPR SSKFSNPMKS NASLAPNGLS TFYSEHSCSK GRVSSLYPFQ
     KKRTYVREYF GEPPEHNLLT SSSDQFRRIR ADNAENFTFP DDSGVRCIGA EVFFHMLIRS
     GASEQYASKE WVKNHYKWII WKLGCYERCY PTKSSGKILT ISNVLEELKY RYEREVNHGH
     RSAIKRILEG DASPTSMMVL CISAINSNYD PKIEVTSLGL GDAENHSVAA AKVELTDGWY
     SVDALLDVML LKQLNSGKLF NGQKLRIWGA GLCGWVGPVS PLEVPRTANL VLHINGTYRA
     QWADRLGFCK GVGTPLAFKC IKTNGGQVPL TLFGITRIYP VLYKERLHNG SSIVRSERME
     NKVVQSYNQR RSIIVESIVS DFQRGIKHSH AYNDSESEEG AKILKVLETA SQPEVLLAEM
     SPDQLSSFAK YQAKMEAIRH SDMEKSIEKA LENAGLGKRE VNPFMRVRVV GLTSRTYQRK
     DSPKEGLITI WNPTEKQQAE LVEGKAYKVA GLLPTNTDAD TIYLQARGST TWQPLSLLEV
     EHFKPFFTPR KSVVLSNLGE VPLSSEFDIA AFVVLVGEVY KGAQQMKQWV FVTDSSISDL
     QSEEFSDCLL AICFCSPYID DDSSVPFNRN LAGSTVGFCN LIKRAKDQVN HLWVAEASEN
     STYFLSFDTP PCSHLKDAAL SAERWGKTSE LITDKLREKV SFIIGDHKG
//