ID A0A2P5FCU3_TREOI Unreviewed; 1464 AA.
AC A0A2P5FCU3;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=TorTNL30 {ECO:0000313|EMBL:PON95610.1};
GN ORFNames=TorRG33x02_084390 {ECO:0000313|EMBL:PON95610.1};
OS Trema orientale (Charcoal tree) (Celtis orientalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Trema.
OX NCBI_TaxID=63057 {ECO:0000313|EMBL:PON95610.1, ECO:0000313|Proteomes:UP000237000};
RN [1] {ECO:0000313|Proteomes:UP000237000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON95610.1}.
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DR EMBL; JXTC01000043; PON95610.1; -; Genomic_DNA.
DR InParanoid; A0A2P5FCU3; -.
DR OrthoDB; 513490at2759; -.
DR Proteomes; UP000237000; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF588; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000237000}.
FT DOMAIN 15..179
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1333..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1464 AA; 169342 MW; 918E6C3F7139DE56 CRC64;
MGPDDQLPPT QSRPKKYDVF VSFRGEDTRK SFTSHLHKAL LHQNIETYID ERLVRGEEVS
KSLLDAIQES RISVIVFSEN YANSSWCLDE LVHILRCKDG NGQIVLPVFY HVNPSDVRRQ
QGSYGAAFGK LERRFKDEIV HKWRTALTTA ANLSGWDASI TRNDSELVET IVKDITEKLN
YRSSSRSHLK GLVGIENSIK EVESLLLSSS SDARIIGIWG MGGLGKTTLA TAIFRHLYCQ
FEGHCFLPNV REDWNIQGSS YLQNKFFAQL WKQKDLDMEN IQSIKERLYR RKLLIVLDDV
EDLEQYERLV EDRDWLNSES RVIITTRNKQ VLRNIGVHGI YKLKQLQGHD AIQLFCCYAF
KRNFSPESYV EMSTKLVNYC KGLPLALKVL GSHLYSKRKE EWRSTLNKLK VVPNKKIHNV
LKISYDGLDR EEKDIFLDIA CFFQGKRKNF VEEILDDHGC FADVIQVLVD KSLVTISCDG
ELRMHDLLQE MGWEITRGNQ CHRELGKQSR LWTTDDICHV LRSNTGTTKI EGIILRGAIR
EDINLKPIVF RKMRRLRLLQ ISVNKGQCQF HLPQGIHSFP GELRYLKWDN YPSKSLGLHT
TPRNLVKLDM PSSQLEKLWN GFKNDLENLK FVNLRFSKKL TCLPDLSQSN LRRLDLQGCT
SLVELPPLRF QHVLDKLTKE TDVFLINNAD MYIFPELDIS LLKNSWTYDI DVYWLNLQGC
TNLKTLSKMS GNIKYMCLRW TAIEELHYSS IRSLNHLILI DLKDCKCLKN LPSDICKMGS
LKYLDLGGCL SIDKFPELPE NIRGLDLSGT SVEQIVSSSF ERLPYLETLY MNSCARLEAL
PPSICKLKSL KRLTFSYCPK LKSFPEILEP MECLDVLYLN ETCLKELPSS ISNLVRLNFL
KLSYCKNLVS IPTSFCKLKS LKRLIISHCS KLKMFPEIME PMRYLQFLYL NGTGIKEIPS
SIESLVGLHL LELSECKNLE YVPSSICKLK FLKKLILSYC SNLKSFPQIW EPMGHLEDLL
LIGTGIKELP WSIGNLINLK CLSLNWCENL EFVPASIYYM RSLNVLSLME CPRLKSLPIV
GVNLQEINVD LSYANILKIC NWLDSSSSLE MLDPTGTTTG RIPIHISRNH WERKTFIKMC
KCSFHQPFLS STFARKGLFF FRNHVGRHQC SIALTRYTQY WFDFETEFPY CEYCLKFDEV
RNILMAEFQL NVLHMAVSSI FICGDHESNH HGISFCYSGN EIPEWFSTCQ AAGSTIDINF
SQLWRDTGFF GFALCIVVDF ENMFLEDPNY LALGCEYHFK TTYGESYKYR WTLQKRHDAY
PFDDSLRRQQ DAYSHDDSLQ GQHNTSSDAD SHQRRHDAYS HDDSDSNSDS ENAMELDWSS
CVFIWHLYED NYYEYHGATG ASFDFYIDGQ TNAAFGKQRI RKCGVRMLSL QDAREFGILK
YVPGENSNSN TIEPHHKRIK LSNW
//
