ID A0A2P5FIB2_TREOI Unreviewed; 1145 AA.
AC A0A2P5FIB2;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=RNA exonuclease 4 {ECO:0000256|ARBA:ARBA00016937};
GN ORFNames=TorRG33x02_067150 {ECO:0000313|EMBL:PON97513.1};
OS Trema orientale (Charcoal tree) (Celtis orientalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Trema.
OX NCBI_TaxID=63057 {ECO:0000313|EMBL:PON97513.1, ECO:0000313|Proteomes:UP000237000};
RN [1] {ECO:0000313|Proteomes:UP000237000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- SIMILARITY: Belongs to the REXO4 family.
CC {ECO:0000256|ARBA:ARBA00010489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON97513.1}.
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DR EMBL; JXTC01000031; PON97513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P5FIB2; -.
DR STRING; 63057.A0A2P5FIB2; -.
DR InParanoid; A0A2P5FIB2; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000237000; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd18044; DEXXQc_SMUBP2; 1.
DR CDD; cd06144; REX4_like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR037431; REX4_DEDDh_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF3; P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Exonuclease {ECO:0000313|EMBL:PON97513.1};
KW Helicase {ECO:0000313|EMBL:PON97513.1};
KW Hydrolase {ECO:0000313|EMBL:PON97513.1};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022728};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nuclease {ECO:0000313|EMBL:PON97513.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237000};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 81..239
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT DOMAIN 667..867
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT DOMAIN 686..901
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 26..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 126259 MW; 7F2E3D58D2BC6809 CRC64;
MGAQPRKNSN KLQLNPNWAN LQKILTSNGS KPSKVSTEKS ESETPTRILG KRKERSDARP
CDSQVLINPL TPLNDDFSIT DAVAMDCEMV GVGQGNKSAL GRATVVNKWG NVIFDEFVRP
VERVVDFRTQ ISGIRPRDLR KAKDFRAVQK KVAELIKGRI LVGHALRNDL KALLLSHPKK
DMRDTSEYPP FLREGYSRAL RHLAAEFLNV EIQNGEHCPI QDARAAMVLY QKNRKEWEKL
VKDQIRLKQK QKKRKPRKKM KLGDDLNANP ASTAEQQQQQ QQQQLNSNSN GDPLGRRELG
KSVVKWISQG MRAMAADFAA AEIGNDNGDF SELQQRMEPG LTFVIQAQPY LNAIPIPLGL
EAVCLKACTH YPTLFDHFQR ELRDVLQDLQ RQSLVTDWRE TRSWKLLKEL AGSAQHKAMA
RKAAVRPKSV QSVLGMDLEK ARAIQSRTDE FTNRMSELLR IERDAELEFT QEELDAIPMP
DESSESSRPI EFLVSHGQAQ QELCDTICNL NTVSTSTGLG GMHLVVFKAE GNHKLPPTTL
SPGDMVCVRT CDSRGAGATS CMQGFVNNLG EDGRTISIAL ESRHGDPTFA KLFGKNVRID
RIHGLADVLT YERNCEALML LQKNGLRKKN PSVAVVATLF GDRDDIAWLE ENHIVDWGEE
ELSGEFISET LDESQRRALA LGLNKKRPIL VIQGPPGTGK TGLLKELIAL AVQQGERVLV
TAPTNAAVDN MVDKLSKIGL NIVRVGNPAR ISSNVASKSL GEIVNSKLAN FRAEFERKKA
DLRKDLSHCL KDDSLAAGIR QLLKQLGKTL KKKEKEAVRE VLSSAQVVLA TNTGAADPLI
RKLDTFDLVV IDEAGQAIEP ACWIPIQQGK RCILAGDQCQ LAPVILSRKA LEGGLGVSLL
ERAASLHGGL LATKLTTQYR MNDTIASWAS KEMYEGSLKS SPIVSSHLLV DSAFVKPTWI
TQCPLLLLDT RLPYGSLSIG CEEHLDPAGT GSLYNEGEAD IVVQHVFSLI YSGVRPTAIA
VQSPYVAQVQ LLRDRLEELP EAAGVEVATI DSFQGREADA VIISMVRSNT LGAVGFLGDS
RRMNVAITRA RKHVAVVCDS STICHNTFLA RLLRHIRYVG RVKQAEPGSF GGSGLGMNPM
LPSIS
//