ID A0A2P5FJT5_TREOI Unreviewed; 1871 AA.
AC A0A2P5FJT5;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN ORFNames=TorRG33x02_061260 {ECO:0000313|EMBL:PON98052.1};
OS Trema orientale (Charcoal tree) (Celtis orientalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Trema.
OX NCBI_TaxID=63057 {ECO:0000313|EMBL:PON98052.1, ECO:0000313|Proteomes:UP000237000};
RN [1] {ECO:0000313|Proteomes:UP000237000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PON98052.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXTC01000027; PON98052.1; -; Genomic_DNA.
DR STRING; 63057.A0A2P5FJT5; -.
DR InParanoid; A0A2P5FJT5; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000237000; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000237000};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 2..257
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1054..1290
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1448..1846
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 293..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1590..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1871 AA; 201965 MW; DEC6D9E68970E3AB CRC64;
MLTNVFKIGG LHQISWFQFL PHESDWTSLP DNSVKVEQKD AATTLVLSSH LQLQKEGFLS
TWTNSFVGPW DPSQGLHNPG GIGVHDEKIK LWLFLPGHHS SVVESAQATV SRLRVVKFGL
WLAPGDSEEV ATALSQALRN CIERALYELS YMRFGDVFSK FRPSQSEETF RRGQHTVEFI
FAATEEGIFV HAIISSKHIR ALSCGDLERV AKQSSSNSSY KLPVIVSPHG IRGRLTGCCS
DDLVKQLYFS SSKFKASNGF IGLPNHVSQG SGCQLGGQQC YVEVTLGCHR SGSDEQLHSN
SNSNKNLPKH HVGESPALGI ADQKGALDNM SILAAELDRT LIAWFSFLCA LGSKRPRAGM
TESFGQMGAA TNFTVQDSYK SDLGSVEVSN SVITGVANEQ IGSFWDWDDD DRDVGTDIRA
LLHEFGDFGD FFENDALPFG EPPGTAESQA LMFSAPDCGD ILSSPVGIMD VSDPLLSAEG
FTSFDSFNPP PPAANDEIVS KNQGVINTSS SSGLVNHSLA SSTTTSEFDH IIKAEALMTF
APEFGAVEAP SSELSSSIFR SPYFPKSRKV ESSSSSSNNY VYGATPPSSP CFDGTDEKSG
MLTNSKSCTI KQSSSGTVQS KNCYTLVENV KDQHDKRSSN NSVVTCDGMA ASLSNVISVN
ATNSAQRKLP DSTFDSDSLF LSMKTVLATE IECIMYQASM CRIRHTLLSS SSPTSAGMGR
LPSTILNQLP SDPSIMTDNL SGKFEVKKKE SIPVRIAGDI DGRMLDGHLN APVGVWRSVG
APRISKPTNS PNMEVSQSLP HNAFNEEGIL SYGQRQPLQE LLDGMALLVQ QATSFVDLAL
DTECGDGPYG LLALQEQWRK GFSCGPSMAH AGCGGTLASC HSLDIAGVEL IDPLSADVYA
SSVISLLQAD IKTALKSAFD ALDGPLSVTD WCRGRNQSGE AGNTGDGYSA ESTLSESSSA
AVSTGEPMSP SQTSGGPSGL KDGVKMDDTC QKRSNQENCS SEADLQMGSR LRPTLFVVPL
PSILVGYQDD WLKTSANSLQ FWEKAPFEPY ALQKPITYGV VCPDIDPLTS AASDFFQQLG
TVYETCKLGT HLPQSFGNQM EVDSGKCSTA GFVLFDCPQA MRIESGNASL VGSISDYFLS
LSNGWDLTSY LKSLSKALKA LKLGPCLSTN AKEGSSSSCM VIYVVCPFPE PTAVLQTVVE
SSVALGSVIF QSDRERRSIL HSQVAKALSC STAVDEASIS NVSVLSGFSI PKLVLQIVTV
DAIFRVTSPS LSELVTLKEI AFTVYNKARR MSRGSSNDVV QSSSLSTRSQ LVLTQMSSHN
PGMWKDCIGP RITGHSLPRE GEIDSSLRPG AWDNSWQTRA GSLACDPNRM GDYFLHDEIR
YMFEPLFILA EAGSLENGYT PFASGNIASE SSKSLLDDSS GGYMQNASSA GSGDSASNSH
IDGSDMDKAS PSLHCCYGWT EDWRWLVCIW TDARGELLDS QIFPFGGISS RQDTKGLECL
FVQVLQQGCQ ILQACSSDTG VARPRDFVIA RIGSFYELEY QEWQKAINSV GGSEVKKWSL
QLRRSVSDGI PANSNGTSLQ QQEMSLIQDR NLPSSPSPLY SSPHSKTSGF MKGGLGQPAA
RKHIMSGHTV IDSSKGLLQW VQSITFAAIS VDHSLHLVSQ ADSSSPGGTQ GSLYTGPSGY
LEGFTPVKSL GSTSASYILI PSPSMRFLPP TPLQLPTCLT AESPPLAHLL HSKGSAIPLS
TGFVISKAVP SMRKDSRNNL KEEWPSALSI SLIDHYGGNN FSQEKIVRGL IKQGRRSSSS
EPREFEIETH LILESVAAEL QALSWMTVSP AYLERRTALP FHCDMVLRLR RLLHFADKEL
SRHPEKSQTM G
//
