ID A0A2P5G287_TREOI Unreviewed; 1318 AA.
AC A0A2P5G287;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=TorRG33x02_004330 {ECO:0000313|EMBL:POO04129.1};
OS Trema orientale (Charcoal tree) (Celtis orientalis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Cannabaceae; Trema.
OX NCBI_TaxID=63057 {ECO:0000313|EMBL:POO04129.1, ECO:0000313|Proteomes:UP000237000};
RN [1] {ECO:0000313|Proteomes:UP000237000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. RG33-2 {ECO:0000313|Proteomes:UP000237000};
RA Van Velzen R., Holmer R., Bu F., Rutten L., Van Zeijl A., Liu W.,
RA Santuari L., Cao Q., Sharma T., Shen D., Roswanjaya Y., Wardhani T.,
RA Kalhor M.S., Jansen J., Van den Hoogen J., Gungor B., Hartog M.,
RA Hontelez J., Verver J., Yang W.-C., Schijlen E., Repin R., Schilthuizen M.,
RA Schranz E., Heidstra R., Miyata K., Fedorova E., Kohlen W., Bisseling T.,
RA Smit S., Geurts R.;
RT "Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-
RT legume Parasponia.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POO04129.1}.
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DR EMBL; JXTC01000001; POO04129.1; -; Genomic_DNA.
DR STRING; 63057.A0A2P5G287; -.
DR InParanoid; A0A2P5G287; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000237000; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223:SF375; ABC TRANSPORTER C FAMILY MEMBER 11-RELATED; 1.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:POO04129.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..278
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 312..534
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 614..897
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 934..1168
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 556..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 147565 MW; F627CEEC2C5AB98C CRC64;
MGIHLAMAYM YEIIVMSFCS YRTQSMQRGD PAWIGYIYAF LIFAGVTFGV LTESQYFQNT
MRVGFRLRST LVAAIFRKSL RLTHEGRKNF PTGKITNMIT TDANALQQVC QQLHGLWSSP
FRIIIAMVLL YQQLGVASLF GALMLVLMLP VQTIIISKMR KLTKEGLLRT DKRVGLMNEI
LAAMDIVKSY AWEGSFQSRV QGIRNEELLW FRKAQLLSAF NSFILNSIPV VVTVVSFGIF
TLLGGDLTPA RAFTSLSLFA VLRFPLNMLP NLLSQVVNAN ISLQRLEELF LAEEKVLKLN
PPLQPGLPAI SIKDGNFSWD QKADKPTLSN INLDTPVGSL VAIVGGTGEG KTSLISAMLG
EIPQVSDASV VIRGSVAYVP QISWIFNATV RENILFGSAF EPARYWKAID VTELHHDLDL
LPGHDLTEIG ERGVNISGGQ KQRISMARAL YSNADVYIFD DPLSALDARV ARQVFNNCIK
QELIGKTRLL VTNQLHFLPQ VDRIILVCDG MVREQGTYEE LTKNGKIFQK LMENAGKMGE
NIEEEVDSED FFQKSSMPAS NGEINESSTN TTNSKKGKLR KSVLIKQEER ETGVVSWNVL
MRYKNALGGM WVVIILLLFY LLTEILRVSS STWLSFWTSQ SKSKSYKPGF YILIYALLSS
GQVTVTLANS FWLIVSSLHA AKRLHDTMIH SLLRAPMVFF HTNPTGRIIN RFAKDLGDID
RNVANLMNMF LGQVWQLLST FVLIGIVSTI SLWAIMPLMI LFYMAYLYYQ STAREVKRLD
SITRSPIYAQ FGEALNGLSS IRAYKAYDRI ANINGKSMDN NIRFTLANLS SNRWLSIRLE
TLGGIMIWLT ASFAVLQNGR AENQVEFAST MGLLLSYTLN ITNLLSGVLR QASRAELSLN
AVERVGTYID LPSEAPEIIE NNRPPPGWPS SGSIKFESVV LRYRPGLPPV LHGLSFTISP
SEKVGIVGRT GAGKSSMLNA LFRIVEMEKG RIMIDGCDIS KFGLTDLRKI LSIIPQSPVL
FSGTVRFNLD PFSEHNDADL WEALERAHLK DVIRRNPFGL DAEVLEGGEN FSVGQRQLIS
LARALLRRSK ILVLDEATSA VDVGTDALIQ KTIREEFKSC TMLIIAHRLN TIIDSDRILV
LDGGQVLEYD SPEELLSNGE SAFSRMVQST GSANAEYLRS LVLVEKQNKT GREENKHLIS
QRRWLASSQW SAAAQYALAV SLAASQNDLQ QSDVEDENNI LLKTKDAVIT LQGVLEGKHD
HDIDETLNYF QISRDSWWSA LYRIVEGLAV MSRLSQNRFQ RLDDDFEDTS IDWDQSEI
//
