ID A0A2P5HYU9_9PEZI Unreviewed; 738 AA.
AC A0A2P5HYU9;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
DE Flags: Fragment;
GN ORFNames=DHEL01_v206170 {ECO:0000313|EMBL:POS75428.1};
OS Diaporthe helianthi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Diaporthaceae; Diaporthe.
OX NCBI_TaxID=158607 {ECO:0000313|EMBL:POS75428.1, ECO:0000313|Proteomes:UP000094444};
RN [1] {ECO:0000313|EMBL:POS75428.1, ECO:0000313|Proteomes:UP000094444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7/96 {ECO:0000313|EMBL:POS75428.1,
RC ECO:0000313|Proteomes:UP000094444};
RA Baroncelli R.;
RT "Polyketide synthases of a Diaporthe helianthi virulent isolate.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POS75428.1}.
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DR EMBL; MAVT02000488; POS75428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P5HYU9; -.
DR STRING; 158607.A0A2P5HYU9; -.
DR InParanoid; A0A2P5HYU9; -.
DR OrthoDB; 2689800at2759; -.
DR Proteomes; UP000094444; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11041; CYP503A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR46206; CYTOCHROME P450; 1.
DR PANTHER; PTHR46206:SF6; CYTOCHROME P450 MONOOXYGENASE GLIF; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000094444};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..738
FT /note="Major facilitator superfamily (MFS) profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015120903"
FT TRANSMEM 520..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 523..738
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 485..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 738
FT /evidence="ECO:0000313|EMBL:POS75428.1"
SQ SEQUENCE 738 AA; 81024 MW; ED0CFC1088F2AC99 CRC64;
MHVPILEYLS ALLSRPLAVF AFLGICTSLD EANRKYPDQP YMVPFQDPTV IIPAYCVEPL
KNLPDSRLSP NGSMYDRFAI GWTGSGWIGT ELAHSIKYDL AKELDDFFGT VQDEIQYSAN
KSLPALDGWT TLEPQPALVQ IVGPVLGRMM VGAPLNRDEA WLSASIDHAM AVVMYSGWLR
QFPPVLRPLV APFLPWKKMV DKSKTGIAAA IQPMVDHNLH RQEKLSDTPR AEQGRLVQWL
LKRYRPKENP SFSPSLIDRD HFSLCFAAIH GPTFLIVQAI IDLASHPKYV DLLRQEIDRV
LSETPFEQWT RKDVASLGMR DAVGWLRKTH RPVTLSTGHV IPPDTLSAAT NPYYNPAATP
WIKDPQEFRP ERWIMADDSD PSQDAGFRFG SATTDSLIFG YGKHACPGRP FGVTVVKSIL
AYIVTSWDVR LAGSHVGRPE NICMDFMHAT WASIILFSLC APRILRTPHS YGLRWRITTF
SKDAPEMDKQ RAIPPEKPPQ DAVGQEEDTP AAPPKKPLSF WLVFFALCLL GLSTALEATI
VTTALPTIIE TIHVGSHYSW VGNAFLLSSA VVQPFIGQLA DVFGRRWPLI FVTACFVLGS
GIAGGATGAG MLIGGRTVQG LGAGGILVII DIVMSDLVPL QERAKLLGLV RMTGALGSSI
GPIVGGAIAK ADWRWCFYLN IVTGGLALVY LVVFLDLKHE PKPLGVALAS IDYAGAALFM
ASVTSCEFYA SITPPLTI
//
