ID A0A2P5I3A3_9PEZI Unreviewed; 2209 AA.
AC A0A2P5I3A3;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:POS76982.1};
GN ORFNames=DHEL01_v204618 {ECO:0000313|EMBL:POS76982.1};
OS Diaporthe helianthi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Diaporthaceae; Diaporthe.
OX NCBI_TaxID=158607 {ECO:0000313|EMBL:POS76982.1, ECO:0000313|Proteomes:UP000094444};
RN [1] {ECO:0000313|EMBL:POS76982.1, ECO:0000313|Proteomes:UP000094444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7/96 {ECO:0000313|EMBL:POS76982.1,
RC ECO:0000313|Proteomes:UP000094444};
RA Baroncelli R.;
RT "Polyketide synthases of a Diaporthe helianthi virulent isolate.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POS76982.1}.
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DR EMBL; MAVT02000312; POS76982.1; -; Genomic_DNA.
DR STRING; 158607.A0A2P5I3A3; -.
DR InParanoid; A0A2P5I3A3; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000094444; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF53; ATROCHRYSONE CARBOXYLIC ACID SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000094444};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..439
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2128..2205
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2209 AA; 239577 MW; 7722449E5EC07A47 CRC64;
MGESLIPEDD AVVPIAIVGT ACRFPGDGDN VESLLEMLKE GSDAWTEFPR DRLNIDGFYH
PSGQRQGSIG FRGAHFLKDD VRGFDAAFFN ISQAEAHAID PQQRILLEVT YQALENAGHT
KESIELSETS VNVGTFVKDY EQIILRDPDW APQYAATGTG AAMLSNRISY QFNLRGPSQT
VDTGCSAGLV AVHNCCQDLR TGRATMAIAA GVGLILTPAT MMPMTALNFL GKSGKCFTFT
DKAEGYGRGE GVGVVVLKRL DDAIRDNDTI RAVIRGSRIN QDGRTPGITM PSSDAQLSNI
EAVYKDAGLD VDQTAYVECH GTGTPAGDPK ECFAVSRAFC GGRDADNPIL IGSIKPNIGH
LEGAAGIAGL IKAVLAVERG QIPKNLYFDP SAGNPEIKFD EWKIKVPTSL TNWPLSGLRR
ASVNCFGFGG TNAHVILDDA GSYLAERCLP GKHRSLPTTV SAGLAKPTTF ASTQLIFVSS
HERDGIARIS SGHVAYVIAH ASEPNLLANY AYTSSRRSSL EFKACFVAQS AADLQQRLNA
PERLSVQRFL PSDDAAPTLA SVFCGQGAQW YAMGRELMEF EPFSSSLVAA SKYLSKIVAS
DFDLLEELMH DYPCLSRINE PRIAQPATTA IQIALVDLLK ASHILPTAVV GHSSGEIAAA
YAAGYLTRED AWLIAFRRGE YAQSLQYSRL NAEGLMMAVG LSASQAQEYI RRVPLGTIVV
ACENSPVSVT LSGDKDQILY LAQEMDEDGV FHRVLVVSTA YHSHHMHLIA QSYQQSLQAV
RPLISAQGSR MFSSVTGKEI FARQVGAEYW SRNLTSPVLF CQAFSDMYEA VKPKLVLEVS
PAITLAKPIQ EIVASLSMGK AKTELPHIPF LKRNEHASVS ALTALGDLWA RGFPVDFSWV
YRSKEGTLPQ ILVDLPPYPF NHSKNYWFES HLGTALRDRS HGREDLIGAP LVESTPRNSQ
WRGFLRLDEN PWLTDHKIQK VIIYPAAGLI TMALEAARQC SDPSLRVDSY RISNFLIVKP
VIIPTSQHGI EHMLTTKALG VPPPDAIKGI AAYSFSIETR TEHGPWQENA NGLINITYDG
KSAGEATTSS NRCRDYRDTY WRLRSECLQE ISASSLYERL DGIGMNYGPL FQNIGALARS
QHSCTSIVRI PDTKSKMPAQ FEYDHLIHPA TLDGMFQTMF AVGDETMVPS RIRQIYFSPD
MLKGAGAEFH GYAIAQRKGF REALADIVMS DAIFSKPMVV VDGMESIKLP SSGASGFLPS
NRHLCSEHVW QELYPILPGT HGLPIRHGVP LIVLLPDGDS SGATNSLSRA LASPNVEHVR
LSRLTPQQAS QHCISLVEVE QALVHNMSRP AFNQIKLLLQ ATPGLLWVTA GAQMTTETPL
LAPFQGLART IRSEDSSKHI VNLDLGGMRN RYDTTVATSA IQTIFNNSFF ETERGHVPEV
EYSLRDSKLF AARLHPLEAI NSVIENGRDQ ALRVSASAFE NPPQPLKLKF APGSRTANTY
FEVNDAAKQP LGPYDVCITV QRTNLYQVDL DTILGRSSGG SLGVDVFGTV ERVGPCVTKV
TVGSQVVALA SDTVQSLVIV DQIFVHQLHS QSKIRGLSPA ALTGAYHRFN NIAGLSHGDT
VFIHCAAGPY GDGAIRVAQY LGVTVFAAVS NAEQRSELSQ HYGLPLEHIV DASNGDLSWQ
LMHLTAGNGV DCVFSPTTDH LDQSAQCVRD NGHIFLVSNT TLSKVPITPQ HENVSIHKFD
LFEVAKKRPR AIAKAWEEVL GLVLEDRLGS PSPSLTHEEP LEHIDRLWDC MAANPDSHLS
TLHFTSGSPV RVGTNPLTPL VLQPDATYVL AGGLGGLGKA VAGLMADRGA RHLIFISRSG
ARTFTDFEFM SSMSRRGVKV MALPVDICDE NDLGQALAST DMPPIKGAVQ CAAVVADAMW
ETMSYEDWTS ATRPKMMGSW NLHTVLPDDM DFLVFLSSAS GVIGNRGQAN YAAGNCFQDA
LARHRALLGH KNSVSLDLGP VMGAGMLEED DKTLAILKAS GFFTVSLDNF LFLVERAMAG
CTSDALRLPP QVVTGVGTGG LIRQNEVADP FWADTKMFEV LNELDLPDLQ FDPSGSTVLG
SSVSTAISSQ NSGKALVTAL NSANSPDEAA NFALSGCVEY LSFSLSMSPD DMDVDKSLTA
YGVDSLVTSS FRSWVFKNTG VKVSDMEVIG AASIMELARS IAEKGGFGT
//
