ID A0A2P5I6I4_9PEZI Unreviewed; 2032 AA.
AC A0A2P5I6I4;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:POS78118.1};
GN ORFNames=DHEL01_v203496 {ECO:0000313|EMBL:POS78118.1};
OS Diaporthe helianthi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Diaporthales; Diaporthaceae; Diaporthe.
OX NCBI_TaxID=158607 {ECO:0000313|EMBL:POS78118.1, ECO:0000313|Proteomes:UP000094444};
RN [1] {ECO:0000313|EMBL:POS78118.1, ECO:0000313|Proteomes:UP000094444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7/96 {ECO:0000313|EMBL:POS78118.1,
RC ECO:0000313|Proteomes:UP000094444};
RA Baroncelli R.;
RT "Polyketide synthases of a Diaporthe helianthi virulent isolate.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POS78118.1}.
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DR EMBL; MAVT02000212; POS78118.1; -; Genomic_DNA.
DR STRING; 158607.A0A2P5I6I4; -.
DR InParanoid; A0A2P5I6I4; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000094444; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF54; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000094444};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..424
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1951..2028
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2032 AA; 221675 MW; 831E10665650743D CRC64;
MEDDPIAIVG MAVRLPGGVL NTDDFWDLMI NKKSGLIPIP KERWNIDGSW SAEPRWGTIQ
NRDCYMFDSN VQLNRFDTSF FTCGKLESDR MDPMQRQLLE ITRECLDSAG ESKTRGEDIG
CYVGTFSSDW QDDQSMDPHA SGIYRGSGYL DFFQPNRISY EYGWTGPSLL IKTGCSSSMV
ALHLAAEAVK NGSCSSAMAL GCNIMTSVLT SIVFTETGVL SPSGKCKTFD SLADGYGRGE
AVNAVYIKKL SHALRDGNPI RAIIRGSGTN NDGRSLGIMT PNDIVQEKLI RQVYKNAGIS
DLSKTAFFEC HGTGTPTGDP LEASAVARIW GPHGGVLMGA VKPNVGHSEG AAGLTSVIKA
VLALEHKVIP PNIYLEDPSP RIPWASAHLR VPTEPEAWPL DRYERVSVNS FGVSGSNAHI
IIDSYDSFER GQRCNSPDSE TDSGVFIPDL PSNRLLLFSA SHPESLDKQV QLHKDYLKKH
PDQVDNLAYT LAFHREHLGY RSYVVADSQG GFETGQVPIS TSRVNRRLVF VYTGQGAHWA
GMGKSLITSN QAFRSSIQRL DRFLQSLPEA PAWTLEEELM KEDPISSKVG QRGYSHPCAT
AVQIALTDML FSLGLRPGAV TAHSGGEAAA AYATGAITAE AAMAIAYFRG VVIKGENVPK
GTMAAVSLGP KAVEPFLIPG VVVGCENSQL STTLSGDPVC IQHCVDQIGR RHPDVKYKIL
NLETSFHSPW LQPLTGIYRE LMRPYVKDTG SPSCPHFSSV TGQMITSADF GLEYWVENFL
LPVKFNSAMR NILESDPNNT FVEIGPHPAL RTPVHEILRD FPGASCEYVT TLERQQDSSH
SLLLLAGRLF SLGVDDVDLG GIIPKARVIP DLPTYPWHHQ AVHWYEPRNA ARFKHRRYPR
HQLLGSRVLE GNDIEPAWRN TLDIKEAGWL NDHVVNGSMV FPATAYVAMV GEAMRQVAGG
VRPFTVRDVS FTTGLVLLKD KRVEFYTRLI PEGATYDEDG DAWYNFKIMS SDGEHWVSHC
SGYIRSGAEI SPDAETLVEL GHEKATKGLA RHIDTETWYR GASKIGVDWT GMFRGLEDMR
ASVTAEEATA SVFDSYEDSD AYASHPAMLD QLLQINLVAL TNGLMRNFDK IHLPTKLGRL
AVFASQELDM HVFGEAADPT PGDDSEVRDK IFHAVMLSQQ GRPVAVLEGL SISELPVAKR
RGAGDKLLGS HFTCDTDLTM LDSVTRRTLN LNSSVDGTPP PSDQNVVEDV HRAVYLFGWK
YPDADILEIG DACLGVGSAV HVLDALRPDP RRRYFKSYTY ACTDAEALGE TEASLAAEGL
ADVMAVSAED MSLVVRGVDL VVASLSSLLV EDESVQEELQ ELSTMLRPWG RVIVHYDSTD
PENFEKMREL ACEKLEELGF AVFSGTDMSF TLAQLPQPAA LSQTVTVLTT NNEQGLLSAE
QLGQVFKNYD CKVNIVFEVP ENTEPGNIVI SLLDLHSPTF YSLDEASFHP FMTKLTGLRG
SLIWVTPSAL TSCSDPRSAM AHGVVRTARM EGGVDVTIVE VDEPSKSASS LGEALWKISQ
SLSSRRSGGS LDADFDYIIT DGVVQIPRMQ WFDLCDFQAQ HDDSRQVPTL ASGPGEVDTT
MSLSQGNMPK ATAQSLQRSL FRDDATYVLV GGTGGIGRSV ATWMAENGAR SFVFLSRSAA
SPEHEPFLGE LESYPGCRVQ AISGDVSDMN DVERALSLAP ENLPVAGVVQ LSLVLCDNGL
KTMTFDQWQK AIKPRVHGTW NLHKATESLP LDFFLIFGSG GGITGYFGQA NYSASNTYLD
ALVEYRHGLG LPASLIDVGV VGDMGYLTGH DGHSAAFRSA GYLFLTERDV LAAAEVAVAH
SNDRGPLHSF CLGAVPDMPL AEPGNRINWK RDVRFGVAHY LFGAGERAKH RETPGRGGYE
DGGAPGDGFN LLNIADLATS DPNNPKWRDP ATIEGLANAL CEALAEILMQ PVDGFSVRTS
LPSLGLDSIV SIELVDWIHR NFRVAMTSIE VTQCSSLLHL SGNIVEKLIG SA
//
