ID A0A2P6FFK1_9MOLU Unreviewed; 307 AA.
AC A0A2P6FFK1;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=HPr kinase/phosphorylase {ECO:0000313|EMBL:PQM32236.1};
DE EC=2.7.11.- {ECO:0000313|EMBL:PQM32236.1};
GN Name=hprK {ECO:0000313|EMBL:PQM32236.1};
GN ORFNames=SMSRO_SF021400 {ECO:0000313|EMBL:PQM32236.1};
OS Spiroplasma poulsonii.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=2138 {ECO:0000313|EMBL:PQM32236.1, ECO:0000313|Proteomes:UP000031565};
RN [1] {ECO:0000313|EMBL:PQM32236.1, ECO:0000313|Proteomes:UP000031565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSRO {ECO:0000313|EMBL:PQM32236.1,
RC ECO:0000313|Proteomes:UP000031565};
RX PubMed=25827421;
RA Paredes J.C., Herren J.K., Schupfer F., Marin R., Claverol S., Kuo C.H.,
RA Lemaitre B., Beven L.;
RT "Genome sequence of the Drosophila melanogaster male-killing Spiroplasma
RT strain MSRO endosymbiont.";
RL MBio 6:e02437-e02414(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-
CC serine + ADP + H(+); Xref=Rhea:RHEA:46600, Rhea:RHEA-COMP:11602,
CC Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001120};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr
CC protein]-L-serine + diphosphate; Xref=Rhea:RHEA:46604, Rhea:RHEA-
CC COMP:11602, Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; Evidence={ECO:0000256|ARBA:ARBA00001319};
CC -!- SIMILARITY: Belongs to the HPrK/P family.
CC {ECO:0000256|ARBA:ARBA00006883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQM32236.1}.
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DR EMBL; JTLV02000001; PQM32236.1; -; Genomic_DNA.
DR RefSeq; WP_040094226.1; NZ_PETG01000001.1.
DR AlphaFoldDB; A0A2P6FFK1; -.
DR STRING; 2138.SMSRO_v1c19370; -.
DR OrthoDB; 9778803at2; -.
DR Proteomes; UP000031565; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd01918; HprK_C; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003755; HPr(Ser)_kin/Pase.
DR InterPro; IPR011104; Hpr_kin/Pase_C.
DR InterPro; IPR011126; Hpr_kin/Pase_Hpr_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR NCBIfam; TIGR00679; hpr-ser; 1.
DR PANTHER; PTHR30305:SF1; HPR KINASE_PHOSPHORYLASE; 1.
DR PANTHER; PTHR30305; UNCHARACTERIZED; 1.
DR Pfam; PF07475; Hpr_kinase_C; 1.
DR Pfam; PF02603; Hpr_kinase_N; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PQM32236.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PQM32236.1}.
FT DOMAIN 6..127
FT /note="HPr(Ser) kinase/phosphorylase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02603"
FT DOMAIN 132..301
FT /note="HPr kinase/phosphorylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07475"
SQ SEQUENCE 307 AA; 35180 MW; 654DD681E79F0471 CRC64;
MEKFIVKDIV DRFEYEVLAG AKGLNREVKV YGLNRPGLEL AGFDFEKNNS NRRVVLLSNK
EKLFVNTLTD EIKKERYEYI LNENIPMIIL TEKFTDKVLL TIADKHDCPV VLAKNITTSR
LYQVVLEFFD EHFAPIVEEH ASLINIFGKG ILLKGKSGIG KSEMTLELVK KNHLFVGDDR
IIIQQRNNKL YGQSHEMLKN LIEVRGLGIL DLSKIYGLQV LLDETTIDLV IELIHLEDEQ
YKSIDRLGSE YKYIKILDTQ VPIVTIPVTY GRNVSELVET AVSKLKLEAA GISSMKTLQD
RFKKYSK
//
