ID A0A2P6P4F8_ROSCH Unreviewed; 1102 AA.
AC A0A2P6P4F8;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Putative phosphodiesterase I {ECO:0000313|EMBL:PRQ16808.1};
DE EC=3.1.4.1 {ECO:0000313|EMBL:PRQ16808.1};
GN ORFNames=RchiOBHm_Chr7g0188231 {ECO:0000313|EMBL:PRQ16808.1};
OS Rosa chinensis (China rose).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC Rosa.
OX NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ16808.1, ECO:0000313|Proteomes:UP000238479};
RN [1] {ECO:0000313|EMBL:PRQ16808.1, ECO:0000313|Proteomes:UP000238479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA Bendahmane M.;
RT "The Rosa genome provides new insights in the design of modern roses.";
RL Nat. Genet. 0:0-0(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRQ16808.1}.
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DR EMBL; PDCK01000045; PRQ16808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P6P4F8; -.
DR STRING; 74649.A0A2P6P4F8; -.
DR EnsemblPlants; PRQ16808; PRQ16808; RchiOBHm_Chr7g0188231.
DR Gramene; PRQ16808; PRQ16808; RchiOBHm_Chr7g0188231.
DR OMA; FVFSAYI; -.
DR Proteomes; UP000238479; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004528; F:phosphodiesterase I activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR CDD; cd09122; PLDc_Tdp1_1; 1.
DR CDD; cd09123; PLDc_Tdp1_2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.30.70.2330; -; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR014905; HIRAN.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR010347; Tdp1.
DR PANTHER; PTHR12415:SF3; OS04G0403400 PROTEIN; 1.
DR PANTHER; PTHR12415; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF08797; HIRAN; 1.
DR Pfam; PF06087; Tyr-DNA_phospho; 2.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PRQ16808.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000238479}.
FT DOMAIN 77..147
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 498
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT ACT_SITE 926
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT BINDING 500
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT BINDING 928
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT SITE 954
FT /note="Interaction with DNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ SEQUENCE 1102 AA; 122444 MW; 8C8C4D88ACE46B71 CRC64;
MKDSSPYSHD SNPSIKNKRV RTHSSLIPCK KPRTPRPLGE PTTTAALLEL KHLDVPLTSS
ATDSPVNFIR LHPDRPYTIG RSPRRCDFVF ADRRVGSRHC QVFYDFLNRK LCVVDGALVS
ISQFKSRSGG GVGRASLNGV FVNGIRVRGG EAVELSDGDQ VSFACSTGNC CSNPVRIGFV
IHKIVFEEMY VSDNSQGSVI VSNPKGCKRI FASRADGASS SLFTRASFLL SECRRILRSD
DPISYIRTRC RYSFGNGFSI DNVIRAPSSD ISRSGVKRKG SMLCETSQIC CNVKSKVQST
SVMQHCDRVV SSESNSDLAA VCVQGDDLDM QDDEVQVPSD TRVADGNFGT SSFNLRSTDN
LPHVGDFVKD KTCSKNVGLQ PGKNFYLNRL AFEDQSSSSR HSVISLPELL HPVQSISQIF
IATFTSDILW FLSTCEIPSH LPVTVACHNT ERCWSSSTEN RTSAPYPEFP NLVVVHPPFP
EAIAFGEDLK RHGIGCHHPK LFVLQRDDNI RVIITSANLV PTQWNAVTNT IWWQDFPRRS
APDYSSLFTQ FSGREVNQDS KSDFVSYLAG FIATLLTDIP SQAQWIVELA KYDFGGAMGH
LVASVPGIHS YKTPYIMESR HYACAERGPS GSSGMKFLGS VEASVVGLSY LFHNATDANG
AKLKKLASFL RKSCENAKDL SIILTRNTNI PADANAVSIH VSNPIEFSEG DRVQLGFLPR
NIAKWVSPLW DIGMFRFSGY VCPKEALGAA LGGNNKKVRL ILHVLEGPKF QDISKMMQPQ
HVIALCSLVA AIERCTGLWR LQEVLGQYKW PESLDSEFVY GASSIGSINA KFLAEFSAAA
GKKSFQFDSE ESDPEWGCWN ARHESKDPSI RIIFPTIERV KNARCGIFPS KRVLCFSEKT
WQRLRTVDIL HDAIPYPCDR VGHPMHTKVA RRRFQSRTDA SSCGWVYCGS HNFSAAAWGR
SISTPSGLKT NGRGNDNSSL DQMLHICNYE LGIIFTFPQT ETDSSAYQKS TNLDDIVLPF
VVPAPKYKRG DRPATTLAMW QALSELSEKE REKHRQEEME AEAMEEILDE DEVVEATDYV
DKEKEDEKAY AEILWSQSSQ SC
//
