ID   A0A2P6PBG3_ROSCH        Unreviewed;       973 AA.
AC   A0A2P6PBG3;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=AP-4 complex subunit epsilon {ECO:0000256|PIRNR:PIRNR037097};
GN   ORFNames=RchiOBHm_Chr7g0215311 {ECO:0000313|EMBL:PRQ19265.1};
OS   Rosa chinensis (China rose).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ19265.1, ECO:0000313|Proteomes:UP000238479};
RN   [1] {ECO:0000313|EMBL:PRQ19265.1, ECO:0000313|Proteomes:UP000238479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA   Bendahmane M.;
RT   "The Rosa genome provides new insights in the design of modern roses.";
RL   Nat. Genet. 0:0-0(2018).
CC   -!- FUNCTION: Subunit of novel type of clathrin- or non-clathrin-associated
CC       protein coat involved in targeting proteins from the trans-Golgi
CC       network (TGN) to the endosomal-lysosomal system.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
CC   -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC       of two large adaptins, a medium adaptin and a small adaptin.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR037097}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRQ19265.1}.
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DR   EMBL; PDCK01000045; PRQ19265.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P6PBG3; -.
DR   STRING; 74649.A0A2P6PBG3; -.
DR   EnsemblPlants; PRQ19265; PRQ19265; RchiOBHm_Chr7g0215311.
DR   Gramene; PRQ19265; PRQ19265; RchiOBHm_Chr7g0215311.
DR   OMA; ADNNMEI; -.
DR   OrthoDB; 25313at2759; -.
DR   Proteomes; UP000238479; Chromosome 7.
DR   GO; GO:0030124; C:AP-4 adaptor complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR017109; AP4_complex_esu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR   PANTHER; PTHR22780:SF13; AP-4 COMPLEX SUBUNIT EPSILON-1; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF037097; AP4_complex_epsilon; 3.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR037097};
KW   Membrane {ECO:0000256|PIRNR:PIRNR037097};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR037097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037097}.
FT   DOMAIN          51..593
FT                   /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01602"
FT   REGION          698..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          927..947
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..716
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        733..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        927..942
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   973 AA;  107102 MW;  2FFF636213127C8E CRC64;
     MEQLKTIGRE LAMGSQGGFG QSKEFLDLVK SIGEARSKAE EERIVLHEIE TLKRRLSEPD
     IPKRKMKEYI IRLVYVEMLG HDASFAYIHA VKMTHDDNLV LKRTGYLAVS LFLNDDHDLI
     ILIVNTIQKD LKSDNYLVVC TALNAVCKLI NDETVPAVLP QVVELLGHQK EAVRKKAIMA
     LHRFYQKSPS SVSHLVSNFR KRLCDNDPGV MGATLCPLFD LITIDVNTYK DLVVSFVSIL
     KQVAERRLPK TYDYHQLPAP FIQIRLLKIL ALLGSGDKQS SEKMYMVVGD IFKKCDSTSN
     IGNAVLYECI CCVSAIHPNP KLLEQAAQVI SRFLKSDSHN LKYMGIDALG RLIKISPEIA
     EQHQLAVIDC LEDPDDTLKR KTFELLYKMT KSSNVEVIVD RMIDYMISLN DNHYKTYIAS
     RCVELAEQFA PSNQWFIQTM NKVFEHAGDL VNVKVAHNLM KLIAEGFGED DDTADSQLRS
     SAVESYLRII GEPKLPSVFL QVICWVLGEY GTADGKYSAS YITGKLCDVA EAYSNDETVK
     AYAVTAIMKI YAFEISSGRK VDMLPECQSL VEELSASHST DLQQRAYELQ AVIGIDAHAI
     ESIMPSDASC EDIEIDKNLS FLNGYVQQAI EKGAQPYISE NERSGVSSIN NFRSQDQHEA
     LSHSLRFEAY ELPKPLVPSR VPPAAVASST ELVPVPEPSY ARETHQSASL PSVSDAGSSE
     LKLRLDGVQK KWGRPTYSSS ASSTSTSSSH KTTNGITQVD GVSTSNSKAR DTYDLRKPSV
     EISPEKQKLA SSLFGGPSRT EKRPSSGNHK VSKATEKSQV SKAAGAHTDA AVEKTNHEPT
     PDLLDFSDST VTGTAPSIDP FQQLEGLLDQ TEATSTVNNG PAGASKTPEI MGLYADTPVS
     GLSSSVGNPV LTNRDDFNLA SELSNATRTS QVGVSQSNRG PNPKDSLEKD ALVRQMGVTP
     TSQNPNLFRD LLG
//