ID A0A2P6PC52_ROSCH Unreviewed; 1202 AA.
AC A0A2P6PC52;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=RchiOBHm_Chr7g0217981 {ECO:0000313|EMBL:PRQ19511.1};
OS Rosa chinensis (China rose).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC Rosa.
OX NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ19511.1, ECO:0000313|Proteomes:UP000238479};
RN [1] {ECO:0000313|EMBL:PRQ19511.1, ECO:0000313|Proteomes:UP000238479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA Bendahmane M.;
RT "The Rosa genome provides new insights in the design of modern roses.";
RL Nat. Genet. 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRQ19511.1}.
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DR EMBL; PDCK01000045; PRQ19511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P6PC52; -.
DR EnsemblPlants; PRQ19511; PRQ19511; RchiOBHm_Chr7g0217981.
DR Gramene; PRQ19511; PRQ19511; RchiOBHm_Chr7g0217981.
DR OMA; GDERIMN; -.
DR OrthoDB; 946435at2759; -.
DR Proteomes; UP000238479; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:PRQ19511.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Receptor {ECO:0000313|EMBL:PRQ19511.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1165..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 136505 MW; 146A0B01048B3AA9 CRC64;
MSTQRTSPSL PPSAPQLKYD VFLSFRGDDT RKAFTDHLYT ALEHQGIITF RDDPELQKGE
AISPALIAAI EESRFALIVL SQNYASSTWC LDELERILEY MKGRKTVLPI FYDVDPSVVR
KQTGSFREAF TNHEERFRDD KEKVRRWRYA LTEVASFSGW NSKEWYESKL IRDIVEVIWT
KLQPTSFSYA ENLVGIYSRL QPVNFLLDVG VDDVRFIGIW GMGGTGKTTM VRAVYERISR
EFEFSFLLTD VRNSVEKSGL LNLQKQLLSG IWTKKANISD PHEGATIIRR LLGHKKVLLI
LDDVNHSSHL EYLAGNQEWF GSGSRVLITT RNEHLLIRHG VERRLKVEEL NHDDSLQLFS
WKAFNRGHPE EDFLGLSESV ISYAKGLPLA LEVLGSFLHG RDQSEWNSAL GKLGRVCNLE
IFDILKISYN DLDSEEKKIF LDIACFFNGQ DKDRVTEVLT SCNFSAIIGI KVLMERSLLN
LSNGRLWMHD LLREMGHEIV HLESPNEPGR CSRLWLLEDV KHVLTKITGT EAIEGIFVDS
TESGVDVDVT PKSFSMMRKL RYLKIKNGNL PKGLDYLPNS LRILDWTMYP LKSLPSHFNP
QKLLELSLSH SCIKHVWLGT EPLYNLKTIN LSHSLKLVNT PDFKDMPYLE NLFLEGCIRL
YQLDPSIEVL ERLTVLNVKD CKNLVHFASR VRGLKSLKVL NLSGCSKVNK LPNDTGHLES
LEELYLNGTS IKQLPTSAEM LERLSLLNME NCKHLVCLPS SVVGGLKSLK DLNLSGCSKL
DKLPDELGHI ACLEKLDVSG SGIREVPSSI GLLKNLKELS IAGCAAQSPT SWNMMSNPFQ
LLRKRSHIPA GLSLPCLSSL HSLTKLDLSD CNLSEEAMPS GFGCLSSLEI LDLSRNQFFR
LPESISQLSK LVYIGLYQCC KLRTLPELPS HVWVEADNCI SLDTLANQIG QCNSVLQGIF
VNCFKMVENE SCGSIALSLL TRYLKSKTFS VRRRFQFIGP GNEVSEWYNH QRGGSLITLE
LHPGWLSNKF MGFAWCVVFR LLKPLPPLVT WSIQCTLKAN GKDSPRSCSL LGDEWGQPVS
DHIWFFYVPC DDFSHHEWQD IYCQPVFSFQ PRYGDERIMN EEIVQVKKCG VRMVYEEDVE
ELWETLLKQS NVGINTKRCL QHYDDDGASS SASEAHPKRI EQLHLDSAEP SGTPYIHNKK
HD
//
