ID   A0A2P6PCY1_ROSCH        Unreviewed;       562 AA.
AC   A0A2P6PCY1;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN   Name=MLO {ECO:0000256|RuleBase:RU280816};
GN   ORFNames=RchiOBHm_Chr7g0221021 {ECO:0000313|EMBL:PRQ19781.1};
OS   Rosa chinensis (China rose).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ19781.1, ECO:0000313|Proteomes:UP000238479};
RN   [1] {ECO:0000313|EMBL:PRQ19781.1, ECO:0000313|Proteomes:UP000238479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA   Bendahmane M.;
RT   "The Rosa genome provides new insights in the design of modern roses.";
RL   Nat. Genet. 0:0-0(2018).
CC   -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC       cell death. {ECO:0000256|RuleBase:RU280816}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU280816}.
CC   -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC       binds calmodulin in a calcium-dependent fashion.
CC       {ECO:0000256|RuleBase:RU280816}.
CC   -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC       ECO:0000256|RuleBase:RU280816}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRQ19781.1}.
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DR   EMBL; PDCK01000045; PRQ19781.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P6PCY1; -.
DR   EnsemblPlants; PRQ19781; PRQ19781; RchiOBHm_Chr7g0221021.
DR   Gramene; PRQ19781; PRQ19781; RchiOBHm_Chr7g0221021.
DR   OMA; GVIVQFW; -.
DR   OrthoDB; 368831at2759; -.
DR   Proteomes; UP000238479; Chromosome 7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   InterPro; IPR004326; Mlo.
DR   PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR31942:SF9; MLO-LIKE PROTEIN 4; 1.
DR   Pfam; PF03094; Mlo; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW   Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW   Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW   ECO:0000256|RuleBase:RU280816};
KW   Plant defense {ECO:0000256|RuleBase:RU280816};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW   Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   562 AA;  64173 MW;  D461748C26CC4950 CRC64;
     MEEVIQQQRS LAETPTYSVA SVVTVMVFVC LLVQRSIYRF GKWLKKTRRK ALFVSLEKIK
     EELMLLGLIS LLLAQSARWI SEICVNSSLF TSKFYICSEK DYSNTNEKVK LESSFSSPNA
     TDIPAGLINL SSHQCGEGHE PFVSYEGLEQ LHRFLFVLGI THVLYSCVAV GLAMSKIYSW
     RKWENQAGLL ADANLQAKKN KVMRRQSTFV FQHTSHPWSR HRILIWMLCF LRQFKSSIQR
     SDYLALRLGF ITKHRLPHSY NFHKYMVRSM EDEFQGILGI SWPLWGYAIV CIFVNVHGLN
     IYFWLSFIPA ILVMLVGTKL QHVVSSLALE IVEQTGPAVG TEVKPRDDLF WFGKPVILLR
     LIQFIIFQNA FEMATFLWSL WGLKERSCFM KNHVLIVIRL ASGVLVQFWC SHSTVPLNVI
     VTQMGSRCKK ALVAESVRES LHSWCKRVKE RSKHSHAARS VCSLDTTIDE RDEITVASGT
     LSRSSSLDSQ HQVTVAPMEQ PHAVLETTDL PQHEYSFQVA EYLADSVSIS ASQRPTTSEE
     DDDSINGVEE KVDTLLELFQ KT
//