ID A0A2P6PNM1_ROSCH Unreviewed; 285 AA.
AC A0A2P6PNM1;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Putative 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)) {ECO:0000313|EMBL:PRQ23525.1};
DE EC=1.3.1.22 {ECO:0000313|EMBL:PRQ23525.1};
GN ORFNames=RchiOBHm_Chr6g0262341 {ECO:0000313|EMBL:PRQ23525.1};
OS Rosa chinensis (China rose).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC Rosa.
OX NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ23525.1, ECO:0000313|Proteomes:UP000238479};
RN [1] {ECO:0000313|EMBL:PRQ23525.1, ECO:0000313|Proteomes:UP000238479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA Bendahmane M.;
RT "The Rosa genome provides new insights in the design of modern roses.";
RL Nat. Genet. 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRQ23525.1}.
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DR EMBL; PDCK01000044; PRQ23525.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P6PNM1; -.
DR EnsemblPlants; PRQ23525; PRQ23525; RchiOBHm_Chr6g0262341.
DR Gramene; PRQ23525; PRQ23525; RchiOBHm_Chr6g0262341.
DR OMA; AGNFYNH; -.
DR OrthoDB; 2896758at2759; -.
DR Proteomes; UP000238479; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047751; F:3-oxo-5alpha-steroid 4-dehydrogenase (NADP+); IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF35; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:PRQ23525.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..260
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 285 AA; 32052 MW; 4DE66667C10AE4C0 CRC64;
MVSMAWPIIF VFPPPASVFV TAMSVISFAG LANTGFSEVR GKHLQYSKFR KNNSNQSDSQ
KSKQIYISGR TGMQIAYTPA FLAGLTSLVF FPHNDDIRYL LLSLALTIHF LKRLLEVQFV
HKYSGGGTLD TVIPISLSYF MSTVTAIYAQ HLTMTQGLPE PPIDLKNTGI LLFLIGISGN
FYHHYLLSRL RSSSSSSPSN SKSNDDKDYK IPRGGMFELV VCPHYLFEII GFVGFSFISQ
TLYAFAFMAG TAFYLSGRSY ATRRWYLSKF KHFPPNVKAL IPYLY
//
