ID   A0A2P6Q2P7_ROSCH        Unreviewed;       503 AA.
AC   A0A2P6Q2P7;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE   AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN   ORFNames=RchiOBHm_Chr5g0003321 {ECO:0000313|EMBL:PRQ28463.1};
OS   Rosa chinensis (China rose).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ28463.1, ECO:0000313|Proteomes:UP000238479};
RN   [1] {ECO:0000313|EMBL:PRQ28463.1, ECO:0000313|Proteomes:UP000238479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA   Bendahmane M.;
RT   "The Rosa genome provides new insights in the design of modern roses.";
RL   Nat. Genet. 0:0-0(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC       ECO:0000256|RuleBase:RU004914}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRQ28463.1}.
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DR   EMBL; PDCK01000043; PRQ28463.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P6Q2P7; -.
DR   EnsemblPlants; PRQ28463; PRQ28463; RchiOBHm_Chr5g0003321.
DR   Gramene; PRQ28463; PRQ28463; RchiOBHm_Chr5g0003321.
DR   OMA; WVLMISI; -.
DR   OrthoDB; 10858at2759; -.
DR   Proteomes; UP000238479; Chromosome 5.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR   PANTHER; PTHR11206:SF479; PROTEIN DETOXIFICATION; 1.
DR   Pfam; PF01554; MatE; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW   Transmembrane {ECO:0000256|RuleBase:RU004914};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM        52..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        136..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        165..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        198..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        227..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        273..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        350..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        394..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        424..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        454..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
SQ   SEQUENCE   503 AA;  54630 MW;  7B39F44EDB60615A CRC64;
     MDYSSELSEP ILTDKRSSSV QLVSSELEET LSNTELPFFH RLRRATWVEL KILCRLAAPA
     VVVYLLNNVI SMSTQIYCGH LGNLELAASS LGNTGIQVFA YGLMLGMGSA VETLCGQAYG
     AKKYDMLGVY LQRSTILLMA TGIPVMFIYI FSKAILIALG ESATIASSAA IFVYGLIPQI
     FAYACNFPIQ KFLQAQSIVF PSAYISAAAL VVHVVLSWVV IYKLGWGLLG ASLMLSFSWW
     IIVVAQFVYI LLSPRCKRTW TGFSMQAFSG LWSFLKLSVA SAVMLCLETW YYQIIVLIAG
     LLEDAEIALD ALSVCMTISG WVFMVAVGFN AAASVRIGNE LGAGHPKSAA FAVIIVTSTS
     FIISVVCAIV VLALRNVISY AFTEGETVSN AVSALSPYLA VSIMLNGIQP VLSGVAVGCG
     WQAFVAYVNV GCYYIIGVPL GCVLGFKFDF GAQGIWSGMI GGTFIQTVIL LWVTLRTDWN
     KEVANAKNRL DKWDDKKEPL LIE
//