ID A0A2P6QJV3_ROSCH Unreviewed; 640 AA.
AC A0A2P6QJV3;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
GN ORFNames=RchiOBHm_Chr5g0069061 {ECO:0000313|EMBL:PRQ34446.1};
OS Rosa chinensis (China rose).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC Rosa.
OX NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ34446.1, ECO:0000313|Proteomes:UP000238479};
RN [1] {ECO:0000313|EMBL:PRQ34446.1, ECO:0000313|Proteomes:UP000238479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA Bendahmane M.;
RT "The Rosa genome provides new insights in the design of modern roses.";
RL Nat. Genet. 0:0-0(2018).
CC -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC {ECO:0000256|RuleBase:RU363097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC Evidence={ECO:0000256|RuleBase:RU363097};
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRQ34446.1}.
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DR EMBL; PDCK01000043; PRQ34446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P6QJV3; -.
DR STRING; 74649.A0A2P6QJV3; -.
DR EnsemblPlants; PRQ34446; PRQ34446; RchiOBHm_Chr5g0069061.
DR Gramene; PRQ34446; PRQ34446; RchiOBHm_Chr5g0069061.
DR OMA; ALDWDSY; -.
DR Proteomes; UP000238479; Chromosome 5.
DR GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05236; FAR-N_SDR_e; 1.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF123; FATTY ACYL-COA REDUCTASE 7-RELATED; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF07993; NAD_binding_4; 2.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW ECO:0000256|RuleBase:RU363097};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU363097}; NADP {ECO:0000256|RuleBase:RU363097};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363097,
KW ECO:0000313|EMBL:PRQ34446.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238479}.
FT DOMAIN 17..174
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 330..409
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 541..639
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
SQ SEQUENCE 640 AA; 72855 MW; 2D4847006F44C784 CRC64;
MELESIVAYL SNKTILITGA TGFLGMVLVE KILRVQPDVK RLYLLVRATD AESAAYRMKN
EILGKELFKV LKETWGEDFD SFISQKVVVI PGDVSFENLG VKDVIIMENM CTEIQIIVSS
AANTKFDERY DISLSINTFG VLHMLSFANK CLKLEMLLHI STVRWAAASD RNPTAGDGTP
AKSPMVMEER ETIGDFAGAG HRILANFLRI PITGSRISIT GQLIQVTVRR PPEFAENLTG
KFFAPNRHLL PPNRWAIEVY CPPIDVFCTN SLLLPNRSLL PPIDDYQPSY VCGEKVGLIL
EDSTSINKRV KEMPRFDFEV VEKNLVNEKL NELRTQDASE DVITNTMKDL GIERAKLHGW
PNTYVFTKAM GEVLLSHHSK NNLPFVIVRP PIVSSTYSEP FPGWVQGYRY DSPCTSKHLL
GNWEILLTPI AYESVIAGYC KGKLTCLLLG PMTVMDMIPV DMVVNSMIAA IVVNANKSSG
IIYHVGSSLR NPIKFDDIRS FVVKYFTKYP WINKDEKPVV VRKVPIFKTM ATFRMYIKIR
YSLPLKGLKL VNKVSGQCFQ NIYVKYNQKL RLVMRMVELY RPYMLFKGIF DDTNTEELRK
ITREGYIEVE DFNFDPTCID WEDYIMNTHI PGFLKHVLNK
//
