ID   A0A2P6RHS8_ROSCH        Unreviewed;       540 AA.
AC   A0A2P6RHS8;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   22-FEB-2023, entry version 16.
DE   RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN   Name=MLO {ECO:0000256|RuleBase:RU280816};
GN   ORFNames=RchiOBHm_Chr2g0084281 {ECO:0000313|EMBL:PRQ45988.1};
OS   Rosa chinensis (China rose).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ45988.1, ECO:0000313|Proteomes:UP000238479};
RN   [1] {ECO:0000313|EMBL:PRQ45988.1, ECO:0000313|Proteomes:UP000238479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA   Bendahmane M.;
RT   "The Rosa genome provides new insights in the design of modern roses.";
RL   Nat. Genet. 0:0-0(2018).
CC   -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC       cell death. {ECO:0000256|RuleBase:RU280816}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU280816}.
CC   -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC       binds calmodulin in a calcium-dependent fashion.
CC       {ECO:0000256|RuleBase:RU280816}.
CC   -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC       ECO:0000256|RuleBase:RU280816}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRQ45988.1}.
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DR   EMBL; PDCK01000040; PRQ45988.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P6RHS8; -.
DR   STRING; 74649.A0A2P6RHS8; -.
DR   EnsemblPlants; PRQ45988; PRQ45988; RchiOBHm_Chr2g0084281.
DR   Gramene; PRQ45988; PRQ45988; RchiOBHm_Chr2g0084281.
DR   OMA; ETVHFQT; -.
DR   OrthoDB; 368831at2759; -.
DR   Proteomes; UP000238479; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   InterPro; IPR004326; Mlo.
DR   PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR31942:SF74; MLO-LIKE PROTEIN 15; 1.
DR   Pfam; PF03094; Mlo; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW   Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW   Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW   ECO:0000256|RuleBase:RU280816};
KW   Plant defense {ECO:0000256|RuleBase:RU280816};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW   Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        373..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          472..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  61149 MW;  1E7497A6276A12F1 CRC64;
     MAGGTTLEYT PTWVVAFVCS VIVFISLVVE RLLHYTGKYL KRKNQKPLFE ALQKIKEELM
     LLGFISLLLT VLQGPIEKIC ISEKLASHWL PCKEESKSTS TTAHFQTSSF FSSNYYSRQL
     LVFPAGTARR LLADDAESTS ESGSTGSCPE GKVPLLSTTA LHHLHIFIFV LAVVHVTFCV
     LTIIFGGIKI RQWKQWEDSI VRKEYNPEEV LTQKFTAVQD HDFIRGRFLG IGKNLAFLGW
     LIAYFKQFYG SVTKTDYMTM RLGFIKTHCK GNPNFNFHKY MVRALEADFK KVVGISWYLW
     IFVVIFLLLN VAGWHAYFWI AFVPFFLLLA VGTKLEHVII QLAHDVAEKH IAIEGDLVVQ
     PSDDHFWFHR PRLVLLLIHI ILFQNSFELA FFFWIWIQYS FNSCMMGKIG YVIPRLIIGA
     FVQFVCSYST LPLYAIVTQM GTTFKKAIFD EHVQEGLVGW AKSAKKHQAA LRKAATNGSS
     SNGSSQVSHS SKYKLHSEEA TSVSKTSSAT LELAQVGNKE SSVHVGEIQP HQLPPANDHV
//