ID   A0A2P6RKS6_ROSCH        Unreviewed;       656 AA.
AC   A0A2P6RKS6;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Putative sodium/calcium exchanger membrane region {ECO:0000313|EMBL:PRQ47032.1};
GN   ORFNames=RchiOBHm_Chr2g0095341 {ECO:0000313|EMBL:PRQ47032.1};
OS   Rosa chinensis (China rose).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=74649 {ECO:0000313|EMBL:PRQ47032.1, ECO:0000313|Proteomes:UP000238479};
RN   [1] {ECO:0000313|EMBL:PRQ47032.1, ECO:0000313|Proteomes:UP000238479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Old Blush {ECO:0000313|Proteomes:UP000238479};
RA   Bendahmane M.;
RT   "The Rosa genome provides new insights in the design of modern roses.";
RL   Nat. Genet. 0:0-0(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. Cation/calcium exchanger (CCX) subfamily.
CC       {ECO:0000256|ARBA:ARBA00038187}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PRQ47032.1}.
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DR   EMBL; PDCK01000040; PRQ47032.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P6RKS6; -.
DR   STRING; 74649.A0A2P6RKS6; -.
DR   EnsemblPlants; PRQ47032; PRQ47032; RchiOBHm_Chr2g0095341.
DR   Gramene; PRQ47032; PRQ47032; RchiOBHm_Chr2g0095341.
DR   OMA; IWIMNIA; -.
DR   OrthoDB; 3087817at2759; -.
DR   Proteomes; UP000238479; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR   PANTHER; PTHR12266:SF17; SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000238479};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        255..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        513..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..617
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        629..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          155..296
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          492..644
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   656 AA;  71144 MW;  80974CF4873EA537 CRC64;
     MGGPNCKNAR FRGAFNAICA LVLFFLFYTQ DSFIKNPFLG ASNSVLPPIW SSKVDAFMGN
     RVEIIRRRMA QVNVNVNVTF SNSSGIRVNG SDANYVTEAD PKVCTGLFKH HGFATKCEYL
     IAHPECNPGG HFNYIKFLYC DCGSFSFLGY VALTIWLAAL FYLLGNTAAD YFCCSLEKLS
     SLLNLPATVA GVSLLPLGNG APDVFASIAA FVGKDAGDVG LNSVLGGAVF VTCIVVGIIS
     LCVADKGVQI DRKCFIRDIC FFLFTIFSLA MILVVGKVTV GGAIAFVLIY VVYGFVVAAN
     ELLRKHVRKL RFDVVTPLLP VKGSIFSQGN EEDESIYAGL LESEEGNDVP YLQSKLPQWM
     WASNVAIYSN QSAKSSMDSS RSLWGWKDEE HINESSSSSK VLSILEIPLT LPRRLTIPII
     EEDRWSKGYA VASAVLAPIL LVFLWSTQDD VGSTSVKIAC FIGIVSGVVL GILAYLYTRA
     DQPPRKFLLP WVLGGFFMSI IWFYIVANEL LSLLVALGVI FGINPSILGL TVLAWGNSMG
     DLMSNVALAI NGGDGVQIAM SGCYAGPMFN TLAGLGMSML LAAWSNRPAS YIIPRDSSLY
     FTMGFLVAGL IWSLIVLPRN DMRPDKILGV GLITLYMIFL SLRIAASMGA LSLVVV
//