ID A0A2P6TQP9_CHLSO Unreviewed; 1851 AA.
AC A0A2P6TQP9;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=C2E21_5263 {ECO:0000313|EMBL:PRW56350.1};
OS Chlorella sorokiniana (Freshwater green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=3076 {ECO:0000313|EMBL:PRW56350.1, ECO:0000313|Proteomes:UP000239899};
RN [1] {ECO:0000313|EMBL:PRW56350.1, ECO:0000313|Proteomes:UP000239899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTEX 1602 {ECO:0000313|Proteomes:UP000239899};
RX PubMed=29178410; DOI=10.1111/tpj.13789;
RA Arriola M.B., Velmurugan N., Zhang Y., Plunkett M.H., Hondzo H.,
RA Barney B.M.;
RT "Genome sequences of Chlorella sorokiniana UTEX 1602 and Micractinium
RT conductrix SAG 241.80: implications to maltose excretion by a green alga.";
RL Plant J. 93:566-586(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRW56350.1}.
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DR EMBL; LHPG02000009; PRW56350.1; -; Genomic_DNA.
DR STRING; 3076.A0A2P6TQP9; -.
DR OrthoDB; 661905at2759; -.
DR Proteomes; UP000239899; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR Gene3D; 3.40.33.10; CAP; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF103; PROTEIN DETOXIFICATION 49; 1.
DR Pfam; PF00188; CAP; 1.
DR Pfam; PF00892; EamA; 1.
DR Pfam; PF01554; MatE; 2.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55797; PR-1-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000239899};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 385..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 409..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 483..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 514..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1400..1423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1430..1451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1471..1494
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1548..1569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1575..1596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1617..1639
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1659..1682
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1703..1723
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1743..1761
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1773..1791
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 1803..1826
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT DOMAIN 5..298
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
FT DOMAIN 448..586
FT /note="EamA"
FT /evidence="ECO:0000259|Pfam:PF00892"
FT DOMAIN 622..677
FT /note="SCP"
FT /evidence="ECO:0000259|Pfam:PF00188"
FT REGION 298..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1851 AA; 192078 MW; 5DA981B1760B5D03 CRC64;
MTAGTVLVTG ASGYAAQFVV QDYAQRGWQV GATYWSSQEP QFEGNVKVFK VDLASGEGLA
ACLDALGPLT AVINCAAQAV PAACEGEGEA AARAINIPTQ LLAALESHAK RHGSRPVLVH
LSTDHVYEGS SSMYQEGAEL RPVNKYGRSK ADAEAAVAAA WPGHHVILRP SIICGPPPPN
PTRRGQFLQS VDASLAAKKP STFFDDEWRT PTYISDLVAA CRAAVERCGQ LPPTASERVF
NVGGPERINR VDMALALCKV RGYEPQLVQP GSAASVPRTC ATPADISMDT SRLQAVLGRA
SDGGSSSGGT ESSAAAGSGD GSSSTDASSS SSSSGGGNGN AIEDWLFLRS PKLWQAALEL
GFFNYSATAL QTLGLQLVGA TRASFLVQAT VLLTPLLSML AGYRPGRRVW AACGMALFGC
LLITADEASA EASSSASLGA AGLHLGGDGA ILAAALFYSL AVVRMTGYAR SLPSVQIATW
KSVVLGSLAL GALGVAAANA DGLAALWGGY SDPASWAALG WAGLGPGALA SYLHVMGQKH
VAPAQAQVIF SSKPLWAAGL AWVLLGGEEL GHLTWAGGAA IAAAGLLTCP STAAHLSLQY
SSAKGSVKYP FRGMDVCSWA TYALYLEATS YNYDKPGTSR DALVPIGHFV NIVWANTTRL
GCGYSQCSTM EFVVWCQLAT GDGWCSECDG GACTACWERP AYGQPVGKHK IQLDAASKRC
VSACPSSVKN CKQGKRYSEP YRCPPPGAPA GRPPMSGNAA GAAEPDGSPA AGGSGPTPPA
APAAASATGV STAATLAIAV QQACDQALAG LRGTTPSFAL LFTYQLGTGT AADAELLAAR
LPPGCAVVGC QGLGIIGTNS QASPGSLVDR SNHDPPPEPQ QGVSLLLGAL PGRYVAPFAA
ASAPPGPGAR HKIGRPITVA DAAADREALH AWLGLPEGAE PASILLFCAD DEPSLMSLPH
PHGLLARLQR AWPQVVIQGG ISACSLHYRA PGCGEAGGRA TACSALNYCG LVVCKAPCGR
AAPAPAFVSA ALTLKTAEGA DAVFTHVRLA ETSGNAFAKH PFLGPQPVFL VDSVSADPQQ
LASLFRNEEQ PGAPLPADSA LIHYLLEHPE GGELAFWAAD RSDPGDYDSR VRAGHPVIVM
NMGLKQTAGP SFVFGCVLPV DLSATRAVLE EGQHGPGKML CAQWVRVQGA GAAREVLEAE
VPILLAWPIE REMETVHRLA PQVPLVGVYC PAIIGPNTLS NFCGLRCISD GGVAAPASPS
SKVERGMAAL TVQPRRREEE EQQQQQQQQQ QQQQQQQRQS PFQDDDPQAP LLPTGSGPAA
ADGPAAADAD AAKLGWEDAF EECTELPAIA TQLSATCSSY TLAHHQPPAL AAEEVAGLKA
DDGRCGAAGW GAETRNLLHL AFPIALSNAA TFIASAIGVS FVGRLGGLQL SAAVLAQSVF
NVTGMSAMMG FTGTVDTLCG QAWGAKNYRA FGLVVQRALL VNTAFSLLIM ALWLKSEALF
LALGQKPELS AAAARYMRIL SPSLPCIGIS EALKRSLLAQ RVTAPNTAVN AVIATLSPLF
NWLLIVRWGM GLDGAALAVV CLQATSLLLI SSYVIARNAR LRGSEQAVWH GWSREALQGW
GQYLSLALPS IAMICMKWWS FEALILMSGW LPDATLAVAT MGVCNLTNSV SFMVVFGVSM
AASIRISNAL GAGCPHSARR ATFAALGMTM SSLAVLVAAL LGARGAWVRL LTDVQPVIDA
TLSLMPLFAT SMMLDGAVFS LSSLLRGSGR QKVGALANIA TYWFLAIPLA HHLAFARGWG
LHGLWTGALT ANAVQACLML GIALLFDYAG EARKAAARFA LVTPLMADPE A
//
