ID A0A2P6TYS6_CHLSO Unreviewed; 1446 AA.
AC A0A2P6TYS6;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NADH:ubiquinone oxidoreductase 76 kDa subunit {ECO:0000313|EMBL:PRW59214.1};
GN ORFNames=C2E21_2074 {ECO:0000313|EMBL:PRW59214.1};
OS Chlorella sorokiniana (Freshwater green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=3076 {ECO:0000313|EMBL:PRW59214.1, ECO:0000313|Proteomes:UP000239899};
RN [1] {ECO:0000313|EMBL:PRW59214.1, ECO:0000313|Proteomes:UP000239899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTEX 1602 {ECO:0000313|Proteomes:UP000239899};
RX PubMed=29178410; DOI=10.1111/tpj.13789;
RA Arriola M.B., Velmurugan N., Zhang Y., Plunkett M.H., Hondzo H.,
RA Barney B.M.;
RT "Genome sequences of Chlorella sorokiniana UTEX 1602 and Micractinium
RT conductrix SAG 241.80: implications to maltose excretion by a green alga.";
RL Plant J. 93:566-586(2018).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 75 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005404, ECO:0000256|RuleBase:RU004523}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRW59214.1}.
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DR EMBL; LHPG02000004; PRW59214.1; -; Genomic_DNA.
DR STRING; 3076.A0A2P6TYS6; -.
DR OrthoDB; 19999at2759; -.
DR Proteomes; UP000239899; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR CDD; cd02773; MopB_Res-Cmplx1_Nad11; 1.
DR CDD; cd00464; SK; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.200.210; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR010228; NADH_UbQ_OxRdtase_Gsu.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR InterPro; IPR015405; NDUFS1-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR NCBIfam; TIGR01973; NuoG; 1.
DR PANTHER; PTHR43105:SF13; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR Pfam; PF09326; NADH_dhqG_C; 1.
DR Pfam; PF01202; SKI; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00641; COMPLEX1_75K_1; 1.
DR PROSITE; PS00642; COMPLEX1_75K_2; 1.
DR PROSITE; PS00643; COMPLEX1_75K_3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000239899};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Ubiquinone {ECO:0000313|EMBL:PRW59214.1}.
FT DOMAIN 349..427
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 427..466
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 564..620
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1265
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 152683 MW; 38AC77F68B2DFDF2 CRC64;
MQAVITAQPP AAAAPCHSRR LQPAAALCSP AASSQRSAAA LPRRQLARQA VCSWQRQRAA
RPVAAAAAPR DFDKDRFESA NKDYAKLTQQ IEDTATEVVE GLQGTSLFLV GMMGSGKSTV
GKLVAQAIGY CFFDTDVLIE SVTNKQVREI FAEDGEDNFR EIETQVLAEL SPFKNCVIAT
GGGVPTRAEN WGHMQGGITV WLNGQPTLLA HRVVGDGTES RPLLSQSGEQ SDAEQQQQVD
EYTAAVARLT ALLDERRPLY QDADITVSLE GSGPDADIGA PAMEVAYRVL SAINQRIKDD
AEERKRRMDF EIVREDLPAT MTRLRQLRGV QGWQLRGLAA AAQPAPADDL IECIVDGKPV
KVPKGANVLS ACTAAGVDVP RFCYHERLSI AGNCRMCLVE VEKSPKPVAS CAMPAAPGMN
IKTDTPLVKK AREGVMEFLL INHPLDCPIC DQGGECDLQD QSMVFGSDRS RFTEVKRAVS
DKNLGPLVKT VMTRCIHCTR CIRFAKEIAG TDDLGITGRG RDAEVGTYVE KLMTSELSGN
VIDLCPVGAL TSKPAAFTYR NWELKTTESV DTSDAMGANI RVDSRGVEVI RIVPRLNEEV
NQEWISDKAR FQYDALRYQR LNMPYVKGDK GLQQATWPEA FAAIQKAVAG MKGGEMRAIA
GKLADAESMV ALKDLFNRLG AGDLRSEGGF PDFDADVRSN YLFNSSIAGI DSADAILLIG
TNPRIEAPVL NARIRASNLA GVPVAVVGQQ YDLTYPVEHL GEGADALDKL LKGDYLKRLK
GAQRPLVVVG PGVLQRNDRD AVLQKVHKVV EKADVVREGW NGFNVLHDTA SRVAALDIGF
LPSARARASS TAPKLVYLLG ADDFSEADVP ADAFVIYQGH HGDRGAARAN VVLPATAYTE
KFATYVNFEG RPQSTKTAVP SVGDARDDWK IVRAVSEVVG APLPYNSLED VRRRLADVAP
HFGRRDAVEA PLWLNGEYFK AFAERAKAAK TGGQPLATSI PQFYQTDAIS RASKVMAKCI
KARQSPVPGL HQAAMWRRAA VLLALVLALA ASSAAARPGP TLDEAGDGLL TDARGGATAG
DDTAADSTVQ PSGSGDTTSD DDAWWTTSRG TQASSAAAAT GGAAAQADSE GSLFLQQQLN
ALDAAAESQP AGGSDAAAGQ AQLNQGGAQQ AQQASLGGLA SGSADVDTSG YAQPSGTGTR
AASTVQPLQA ASAQQQHTNT QQQQLDAEGE GDADAAQDDY DTGSTASGSD AEEGEQEEAE
EGEEEGGSQA ATKAGSVYEN DYLDGDDDSG AGSGSSDGGS DESGSNSGSG DGEEEQHSVL
AAAGGGSSLG AAVEQRQLIQ DWDGGASRGS AGSDSELGTE VGELHDGSEG QEAEGDGEDE
DEDMEYSRSS SKGSGSGSMR QEGVGDDKWD ANEDSEPSER VSVQGGAATF DSAAGDDRFT
HGLPGN
//
