ID A0A2P6U4L7_CHLSO Unreviewed; 1206 AA.
AC A0A2P6U4L7;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Integral membrane single C2 domain isoform A {ECO:0000313|EMBL:PRW61258.1};
GN ORFNames=C2E21_0078 {ECO:0000313|EMBL:PRW61258.1};
OS Chlorella sorokiniana (Freshwater green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=3076 {ECO:0000313|EMBL:PRW61258.1, ECO:0000313|Proteomes:UP000239899};
RN [1] {ECO:0000313|EMBL:PRW61258.1, ECO:0000313|Proteomes:UP000239899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTEX 1602 {ECO:0000313|Proteomes:UP000239899};
RX PubMed=29178410; DOI=10.1111/tpj.13789;
RA Arriola M.B., Velmurugan N., Zhang Y., Plunkett M.H., Hondzo H.,
RA Barney B.M.;
RT "Genome sequences of Chlorella sorokiniana UTEX 1602 and Micractinium
RT conductrix SAG 241.80: implications to maltose excretion by a green alga.";
RL Plant J. 93:566-586(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PRW61258.1}.
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DR EMBL; LHPG02000001; PRW61258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P6U4L7; -.
DR Proteomes; UP000239899; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd03124; alpha_CA_prokaryotic_like; 1.
DR CDD; cd00030; C2; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR041891; Alpha_CA_prokaryot-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR045050; Synaptotagmin_plant.
DR PANTHER; PTHR10774:SF190; C2 CALCIUM_LIPID-BINDING ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR10774; EXTENDED SYNAPTOTAGMIN-RELATED; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000239899};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 310..433
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 544..672
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 735..862
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 936..1205
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 423..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1206 AA; 130841 MW; 1FEE20E9B3E4133A CRC64;
MDCAVQGLAA QAAAVPQPLR WLLLGGLLAT IIWTAAVLSL RWSERRWQRL QAATEVEWDE
AALRRLFRES LPAWLSDPHA TRQPDWLNAA TRMLWPHIVA AAEQPAAAGQ LQALLNGSHF
WRPRWLRHSR VEVQAIYVGP SAPRVTAIKA VGPTAGAEGT AAAAASGGCW GAVHSEMAMD
FCFTWNSQME VKLLFYLFPG DDDGGGSRGG NDRKWREALR SLWRLIPRAM LVKIGVRQVV
MRGTGRITLS PLLDRLPVVG GARVSLMGPP DFSYRCHVFG GNPFLLPGLE AWLNSFISTT
ALEPFLFPDG LDVPLFGAAG QLARQEPEGL LEVHVVEAAN LPRMDTWIGK ADPYCRLWLR
DGAKVSTSVR GRTVNPRWDE HFTLIVHSAA HQVLNLVLYD SDVLMPDEEI GRAVVHLRDL
DHSPDAPPAD LWLPLQQPVT ERRRRREAKQ RAKERREGSR RRGTSDGGDS SRGGKLGHAR
RVRGEEGGAA AAAAKDGPSS SDSEGSEDDP RDDVCVLSRQ HTGISSAAEA HAAAAAGGPG
AAEQLRQLGL TDSAVPALLR SGVLTVYIEK AEGLSSRMHD AGFTRNIKVK VSVGDVSKVT
ERSKVALLHR RDPVFNEGME LLVDAETATC QDEQVEVEVF IAHNWRRDSF KGRVLIPLQE
IVRKRRMRGS WPLQDAEGGH LTMELGWQAA AASAYGSGHS PQAPLRARGR SAAERRMAAQ
GNRKPLYVDQ HASASVLVAE FRNAAALLAL PESQQFQFLH HSVYILLDEL VGRHKVYKLF
GSSSGFMLAT NVAEPDPRHA TTLLSCARDL LEQLEQVRLP CGTPLRPVMA LSTGPITSGL
LGTVSLTYQL VGRAVSVARE LSKMQDDLPF VATRSFRDAL APEAATQLVS LGQTRTALCL
LLALAAAGTA RACSHVFFAQ EEHLQAHHRS LLAAAGNWDY AENGADWTGD CTGKAQSPIG
ITTSKLNKDM PSAGRAKLKF GKASGLKVIN TGTAIQVEWD KLEGNEATVP VAADAWGAIF
EEGGVKTGEI KQVPVKPLQM HWHSTCEHVV DGNVCALELH IVTAVDNTTS VKVPEVCNEK
LCLAVFGIKQ ELKKDAYEAG DKFVQTVIDN LPKAVGKDAA TALKDSSLDL DSLLPSDKDY
ATYAGSLTAP PCSEGVQWHV FLESNEILSA AQLDAFQAAF AASTGGRTTN RQIMPVNGRT
ILLSEQ
//
