ID A0A2P7YF57_9ASCO Unreviewed; 746 AA.
AC A0A2P7YF57;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 {ECO:0000256|ARBA:ARBA00015963};
DE EC=2.1.1.220 {ECO:0000256|ARBA:ARBA00012796};
DE AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM61 {ECO:0000256|ARBA:ARBA00033309};
GN ORFNames=C7M61_004967 {ECO:0000313|EMBL:PSK34607.1};
OS [Candida] pseudohaemulonii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=418784 {ECO:0000313|EMBL:PSK34607.1, ECO:0000313|Proteomes:UP000241107};
RN [1] {ECO:0000313|EMBL:PSK34607.1, ECO:0000313|Proteomes:UP000241107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B12108 {ECO:0000313|EMBL:PSK34607.1,
RC ECO:0000313|Proteomes:UP000241107};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida pseudohaemulonii genome assembly and annotation.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the actin family. ARP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010121}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK34607.1}.
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DR EMBL; PYFQ01000020; PSK34607.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P7YF57; -.
DR STRING; 418784.A0A2P7YF57; -.
DR EnsemblFungi; C7M61_004967_t1; PSK34607.1; C7M61_004967.
DR VEuPathDB; FungiDB:C7M61_004967; -.
DR OrthoDB; 176764at2759; -.
DR Proteomes; UP000241107; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0160107; F:tRNA (adenine(58)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.10.330.20; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR049470; TRM61_C.
DR InterPro; IPR014816; tRNA_MeTrfase_Gcd14.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF37; ACTIN-RELATED PROTEIN 2; 1.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF08704; GCD14; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR PROSITE; PS51620; SAM_TRM61; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000241107};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 64..356
FT /note="tRNA (adenine(58)-N(1))-methyltransferase catalytic
FT subunit TRM61 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08704"
FT REGION 288..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 84366 MW; A8F81DE34C03FA3D CRC64;
MSFYECKDII EEGDLVLAFV SRGLIKPFYV TKGEYLNTRF GSFEHDRMVG MKYGSQMAGA
NDKGFVHLLQ PSPELWTISL PHRTQIVYTP DSSYIIQRLG ITSGSRVIEA GTGSASFTHS
FARTVAQDGR LFTYEFHEPR FLEAQKELNE HGLLQVNTIA THRDVCNGGF EISDLPEKFS
LNGSINADSV FLDLPSPWTA IPHLPKVVSQ TSRVGICCFS PCIEQVDKTI EALEANGWTS
IEMVEIQGRR YEARKEMVKD LQDVVKRLKD IQGRKTLGIE SRRLARVGDK KKENQGIKRD
IREVESEDTA LPEPKPKSFN PFGKGIRIKE GDEQFKWKQV TKIEPEIKTH TSYLTLLLTL
VLDQGTGFVK IGRAGTNFPD HTFPSLVGRP ILRAEERNAL VPDNIEIKDI MCGSEASEVR
SLLQISYPME NGIIKNWEDM EHLWDYAFYE KMRTPTEGKK ILLTEPPMNP LKNRETMCDV
MFEKYQFGGV YVAIQAVLAL YAQGLSSGVV VDSGDGVTHI VPVYESVVLN HLTRRLDVAG
RDVTRNLINL LLRRGYAFNR TADFETVRQI KEKLCYVSCD LALDTKLATE TTTLVETYEL
PDGRVIKVGS ERFEAPECLF QPSLVDVEQP GVGETLFNTI QAADVDIRSS LFKAIVLSGG
SSMYPGLPSR LERELKQLWL TRVLKGDPSR FDKFKIRVED PPRRRHMVFI GGAVLANIMS
DKDHMWISKQ EWEEQGPRVL EKLGPR
//
