ID A0A2P7YQR6_9ASCO Unreviewed; 718 AA.
AC A0A2P7YQR6;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN ORFNames=C7M61_002861 {ECO:0000313|EMBL:PSK38302.1};
OS [Candida] pseudohaemulonii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=418784 {ECO:0000313|EMBL:PSK38302.1, ECO:0000313|Proteomes:UP000241107};
RN [1] {ECO:0000313|EMBL:PSK38302.1, ECO:0000313|Proteomes:UP000241107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B12108 {ECO:0000313|EMBL:PSK38302.1,
RC ECO:0000313|Proteomes:UP000241107};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida pseudohaemulonii genome assembly and annotation.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK38302.1}.
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DR EMBL; PYFQ01000006; PSK38302.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P7YQR6; -.
DR STRING; 418784.A0A2P7YQR6; -.
DR EnsemblFungi; C7M61_002861_t1; PSK38302.1; C7M61_002861.
DR VEuPathDB; FungiDB:C7M61_002861; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000241107; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033254; C:vacuolar transporter chaperone complex; IEA:EnsemblFungi.
DR GO; GO:0005516; F:calmodulin binding; IEA:EnsemblFungi.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0008976; F:polyphosphate kinase activity; IEA:EnsemblFungi.
DR GO; GO:0016237; P:microautophagy; IEA:EnsemblFungi.
DR GO; GO:0006799; P:polyphosphate biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0007034; P:vacuolar transport; IEA:EnsemblFungi.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR CDD; cd07751; PolyPPase_VTC4_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF03105; SPX; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000241107};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..152
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 498..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 83692 MW; DF623A05EF1724EE CRC64;
MKFGEHLRKA LIKNYSFYYI DYDDLKHQLK KHLKENDYEW TDEFEEEFLA ALEAELDKVY
LFTKVKNTEV NRRIELAEKY VHEVVDALQN PDTKTKKPLE QDFEDLEEDL SDIIADVHDL
AKFTRLNYTG FQKILKKHDK TTGYSLKPIF QVRLNAKPFY KDNYDNLIVK LSKLYDLVRT
RGNPVKGDSS AGGSQQNFVR QTTKYWVHPD NITELKLIIL KHLPVLVFNA EKEFEPEDSA
ITSIYFDNKD MDLYYGRLRK DEGAEAIRLR WYGGMKSDQI FVERKTHRED WTGEKSVKAR
FALKEKKVNA FLKGEYTATQ AFEKMRNEGK KSAKEIHNLE LLAKEVQYSV LKHKYRPVMR
SFYNRTAFQL PGDARVRISL DTELSMVRED NFDGYDRTHG NWRRMDIGVD WPFSQLPERD
ICRFPYAVLE VKLQTQMGQE PPIWVRDLVA SHLVEAVPKY SKFIHGGATL LTDRVNLLPF
WWPQMDVDIR KPRIQQGYGI SRQQQKPKSS SSGGELDEEE MLLEELNQYS SVHFSNDVNP
LEEDLDENSP LLLPSSYTAR DNSTVSNFFR FLWAKFLHVF NDDRTFTIKP GTDFDINSTF
ASRLPKGKKI CVPIRIEPKV YFAAERTFLA WLSIGMILGA TATALLNFGD KSSIVAAVGF
FITALFTLTY SIIKYIGRTI AIREKKIAQY SDKFGPNMIC FFIFAATFFT FFFKFTEA
//
