ID A0A2P7YRW7_9ASCO Unreviewed; 792 AA.
AC A0A2P7YRW7;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=C7M61_002637 {ECO:0000313|EMBL:PSK38698.1};
OS [Candida] pseudohaemulonii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=418784 {ECO:0000313|EMBL:PSK38698.1, ECO:0000313|Proteomes:UP000241107};
RN [1] {ECO:0000313|EMBL:PSK38698.1, ECO:0000313|Proteomes:UP000241107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B12108 {ECO:0000313|EMBL:PSK38698.1,
RC ECO:0000313|Proteomes:UP000241107};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida pseudohaemulonii genome assembly and annotation.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK38698.1}.
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DR EMBL; PYFQ01000005; PSK38698.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P7YRW7; -.
DR STRING; 418784.A0A2P7YRW7; -.
DR EnsemblFungi; C7M61_002637_t1; PSK38698.1; C7M61_002637.
DR VEuPathDB; FungiDB:C7M61_002637; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000241107; Unassembled WGS sequence.
DR GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.10.275.40; -; 1.
DR Gene3D; 1.10.30.20; Bacterial XPD DNA helicase, FeS cluster domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR InterPro; IPR042493; XPD_DNA_FeS.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PSK38698.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000241107}.
FT DOMAIN 7..295
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 749..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 266..305
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 754..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 91189 MW; A3C8AFBF46F26A06 CRC64;
MKFYIDDLPV LFPYPRIYPE QYAYMSDIKK TLDVGGNCIL EMPSGTGKTV SLLSLTVAYQ
MHYPEHRKIV YCSRTMSEIE KALIELQKLM DYRSSELGYV EDFRGLGLTS RKNLCLHPEV
RQERKGAVVD EKCRRLTNGQ LKLKLESEGV SQEQMIQTPN QLGLCSYHEK LNDFDQHDLL
PQGVYSFESL LEYCKKEGTC PYFTVRRMIS FCNVIIYSYH YLLDPKIAER VSKELSRDSI
IIFDEAHNID NVCIESLSLY LTDDTMKRAS RGANKLADAV DEMKAQDSEK LQNEYEKLVE
GLRQNEIARE EDLFMANPVL PKDLLDEAIP GNIRKAEHFI SFLKRFIEYL KTRMKVLHVI
SETPVSFLQH LKELTFIDRK PLRFCSERLS LLVRTLELAD VEDLNALKDI ATFATLVSTY
ETGFQLILEP FETEGSQVPN PILHFTCLDA SIAIKPVFDR FSSVIITSGT ISPLDMYPKM
MNFQTVIQES YTMTLARRSF LPMIVTKGSD QVSISSRFEI RNDPSVVRNY GSLLIEFSKI
TPDGMVVFFP SYLYMESIIS MWQSMGVLDE VWKYKLILVE TPDAQETSLA LETYRKACSN
GRGAVLLSVA RGKVSEGIDF DHHYGRTVLM IGIPFQYTES RILKARLEFM RDHFQIKEND
FLSFDAMRHA AQCLGRVLRG KDDYGIMVLA DRRFARKKNQ LPKWIAQALY DSDTNLSTDM
ALANAKKFLR SLAQPTNPKD SEGVSVWDLQ QLEEHQRQQQ KKMDKRIEDD VDVEDKGEDD
FMDLDDADLE LL
//
