ID A0A2P7YTC4_9ASCO Unreviewed; 796 AA.
AC A0A2P7YTC4;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=C7M61_001827 {ECO:0000313|EMBL:PSK39224.1};
OS [Candida] pseudohaemulonii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=418784 {ECO:0000313|EMBL:PSK39224.1, ECO:0000313|Proteomes:UP000241107};
RN [1] {ECO:0000313|EMBL:PSK39224.1, ECO:0000313|Proteomes:UP000241107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B12108 {ECO:0000313|EMBL:PSK39224.1,
RC ECO:0000313|Proteomes:UP000241107};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida pseudohaemulonii genome assembly and annotation.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK39224.1}.
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DR EMBL; PYFQ01000003; PSK39224.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P7YTC4; -.
DR STRING; 418784.A0A2P7YTC4; -.
DR EnsemblFungi; C7M61_001827_t1; PSK39224.1; C7M61_001827.
DR VEuPathDB; FungiDB:C7M61_001827; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000241107; Unassembled WGS sequence.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR GO; GO:0071474; P:cellular hyperosmotic response; IEA:EnsemblFungi.
DR GO; GO:0071469; P:cellular response to alkaline pH; IEA:EnsemblFungi.
DR GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:EnsemblFungi.
DR GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000241107};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 383..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 534..561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 700..719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 731..754
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 85..112
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 796 AA; 90412 MW; C171858F654449B7 CRC64;
MALVEVYVPS EESRHILHEI GNLGLMQFKD LNSGVNEFQR AFVQELRTLD NIERQYSFLK
SALDKKGISL NAHPYETNDV QVSDIDEYAQ NAALLESRVH QLSNSADGLQ EKKLELIQYR
SAIKTVDNFF ATGDSREVLP PSVVDESLNS GSKFVTGTID REKIGILQQI LWRALRGNMY
FYTEEIPQLV FDPKRGCDVP KNVFIIFSHG LLIHHRILKI AESLDAKVFD VNMGSDERLR
QIAHLDGELR DLNVVLKETD NALCSELIAV SRDLPKWWEV IAKEKRVYQV MNLCNYDILR
KTLIAEGWVP EDEIQSLTAK VRSLSSSESV PTIVSILETS KTPPTYHRTN KFTSAFQSIC
DTYGIASYQE INPGLPTIIT FPFMFAIMFG DLGHGFLMFL AALILVLKEE HISALKRDEI
FDMAFSGRYI LLMMGAFSMY TGLMYNDIFS KSLTLFSSGW QWPSEFNDGE LVTATQVGVY
PFGLDWAWHG SENSLLFSNS YKMKLSVLMG YLHMTYSYFF SLLNAIYFGS MIDIIGNFVP
GLLFMQSIFG YLSLCIVYKW SVDWVKSQEQ PPGLLNMLIT MFLSPGTVVE PLYSHQSVVQ
LTLLLIALIC VPWLVFVKPF YLKHKMSLKE SSDTYEAIIN EETDFTNPAD ESRLTSLQGG
ESLVTDELEE EEGFGDIMIH QVIHTIEFCL NCVSHTASYL RLWALSLAHA QLSTVLWTMT
LENAFGPTGA LGVIMTVFLF GMWFCLTVVI LVIMEGTSAM LHSLRLHWVE SMSKFFVGEG
YLYQPFEFGQ ILENRL
//
