ID A0A2P7Z702_9PEZI Unreviewed; 379 AA.
AC A0A2P7Z702;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Sterol 24-C-methyltransferase {ECO:0000256|RuleBase:RU362025};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
DE AltName: Full=Delta(24)-sterol C-methyltransferase {ECO:0000256|RuleBase:RU362025};
GN ORFNames=B9Z65_1706 {ECO:0000313|EMBL:PSK43989.1}, C1H76_1454
GN {ECO:0000313|EMBL:TKX26490.1};
OS Elsinoe australis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Myriangiales; Elsinoaceae; Elsinoe.
OX NCBI_TaxID=40998 {ECO:0000313|EMBL:PSK43989.1, ECO:0000313|Proteomes:UP000243723};
RN [1] {ECO:0000313|EMBL:PSK43989.1, ECO:0000313|Proteomes:UP000243723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NL1 {ECO:0000313|EMBL:PSK43989.1,
RC ECO:0000313|Proteomes:UP000243723};
RA Cheng Q.;
RT "Draft genome sequence of Elsinoe australis.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TKX26490.1, ECO:0000313|Proteomes:UP000308133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hillstone_2 {ECO:0000313|EMBL:TKX26490.1,
RC ECO:0000313|Proteomes:UP000308133};
RA Stodart B., Jeffress S., Ash G., Arun Chinnappa K.;
RT "Draft genome sequences of Elsinoe sp., causing black scab on jojoba.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of methyl groups from S-adenosyl-
CC methionine to the C-24 of sterols. {ECO:0000256|RuleBase:RU362025}.
CC -!- PATHWAY: Steroid metabolism. {ECO:0000256|RuleBase:RU362025}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK43989.1}.
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DR EMBL; NHZQ01000297; PSK43989.1; -; Genomic_DNA.
DR EMBL; PTQR01000013; TKX26490.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P7Z702; -.
DR STRING; 40998.A0A2P7Z702; -.
DR Proteomes; UP000243723; Unassembled WGS sequence.
DR Proteomes; UP000308133; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362025};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000243723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Steroid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Steroid metabolism {ECO:0000256|RuleBase:RU362025};
KW Sterol biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Sterol metabolism {ECO:0000256|RuleBase:RU362025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 81..376
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 379 AA; 42235 MW; DC7E63BDA3DFECBE CRC64;
MAPSALEPEN KARDADFHRA MHGKSGQGAG GLRALFQKNA EAGALSGQEY FKHFDNQAAK
DETPEQREAR RNMYASLTRE YYNLSTDLYE YGWGQSFHFC RFSHNEAFKQ AVARHEHYLA
HQMGIQEGMN VLDVGCGVGG PAREICKFTG ANIVGLNNND YQIERATHYA AKEGMSEKVA
FVKGDFMQMG FADNTFDAVY AIEATVHAPS LEGIYSEIFR VLKPGGVFGV YEWLMTENYD
NDNPRHREIR LGIEQGDGIS NMDKISTALK AVKDSGFELL HHEDLAERPD PYPWYWPIAG
ELKYLGSVWD LPLVIRMTKI GRATVHRLVG GLEMIGLAPK GTQKAADNLA LAADSLVAGA
KEKLFTPMYL MVARKPNKA
//
