ID A0A2P8A6G4_9PEZI Unreviewed; 1418 AA.
AC A0A2P8A6G4;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=B9Z65_4919 {ECO:0000313|EMBL:PSK56041.1};
OS Elsinoe australis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Myriangiales; Elsinoaceae; Elsinoe.
OX NCBI_TaxID=40998 {ECO:0000313|EMBL:PSK56041.1, ECO:0000313|Proteomes:UP000243723};
RN [1] {ECO:0000313|EMBL:PSK56041.1, ECO:0000313|Proteomes:UP000243723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NL1 {ECO:0000313|EMBL:PSK56041.1,
RC ECO:0000313|Proteomes:UP000243723};
RA Cheng Q.;
RT "Draft genome sequence of Elsinoe australis.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK56041.1}.
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DR EMBL; NHZQ01000066; PSK56041.1; -; Genomic_DNA.
DR STRING; 40998.A0A2P8A6G4; -.
DR Proteomes; UP000243723; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000243723}.
FT DOMAIN 25..411
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 492..652
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 700..790
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 803..1099
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1109..1301
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 749..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1387..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1418
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 160445 MW; A5C1398C3A864D3A CRC64;
MAPPVVEDVA ASRPTIQDLT GDNHFAQLAR KYWLGKTRVK KVQPNVVKSD LWDVLERDGF
PSGSLLLLEQ LQLLDRYLWP GYSEDSSDHH AILLALLVNV KRQEGVPAWS EFSSQPEQFS
SFFRRILQLS IDESISLTIR TNLLNFIIGA FQSLDTGIIR KECASLVSIG VWHNLHSEEV
RQQLLGRTVQ LGKAWRAAGK RYDSADPDTQ ARLRFERSWL YSLVLDFTNR LYDTEMLSGK
DTVLYCERAV ELLADLLSQL PTRRYVNTLL TDLNLIPVVT LSPAYADEEN GLLRDMTVLL
QHYMTFPIED HTGRELNAAE HDERHNNTLS RLQKVAMKDF KDKLTILALS NFKSLDSRAD
LEGHLKGLSD EELKQLCDAL QFRTFYPQTS LIVRDRQFYL EVLINIHERR PSYREKVRDM
TTLPTETTVY EKTFDRTEEY NGSRPLPVPK LNLQYLTVSD FLWRSFVLYR CESFYEVRKH
VEDTIRRIQP RQAGAGLRFE GFSKMAIPIT KPAVVDVAPP NVGEVHPSQV QVEVSLDVSK
FTPGVRREWE TLRQDDVVYL VTAQAPTQTR ALTNGAARAG DVPRSIKHLR CAEVINVLDD
DGKPLREKQS EMNGSVSRAR KRRLLLKLDA LAYEQDASKP EILDSINLIV RRRGRENNFK
PILESIQHLV LSETPAPTWL QEVFLGYSDP AAATYKRLPN RLKSIDFRDT FLDWPHLVES
LPGKTVEPDE SMNGSFPPPY VLETSTTEVA EARPAKKRRK EKEEAPRTET VENVKVTTYK
PPNAGPYPSD TPRTNTVRFT PAQVEAITSG TQPGLTVIVG PPGTGKTDVA TQIVSNIYHN
IPEQRTLLVA HSNQALNQLF QKIIALDIDE RHLLRLGHGE EELETDADYS KGGRIESLME
RSGQYLAEVH RLAASIGAPG AHGQSCETAE YFDQVYVKPA WTKFWDYAKS TADTSAIVAT
FPFHVFFSNA PQPLFPPSAS LEQVLNIASG CHAHLTQIFT TLSSTRPFEL LRAQRDKANY
LLQHSARIVA MTSTHAAMHR DSISALNFHY DTIIMEESAQ ITEIETFIPF ALQKPTSGTN
PLQRIVLVGD HLQNAPVVQN DAFRSHSHLD QSLFRRLIRL GVPHILLDAQ GRARPSIASL
YAWRYPRLSN LSPTTSLPEF TQANPGFRFP HQFIDVGPYK GKGETTPSPH FVQNLGEAEY
AVAVYQYMRL LGYPASRISI LTTYAGQKAL IRDVLGHRCK GNRLFGMPRA VSTVDRYQGE
QNDYVILSLV RTERTGYLRD VRRLTVALSR ARLGLYVLGR RELFESVLEV KGVFEKLFSG
ELGGEGDKLA LVTGEMYGSC ERGEEDESVD GQGRTVRMEG VEHLGKYVFE MTRAKVEDLK
RGEGRLEEVE EVRVGGSDDE DDEEEVEEVE MEEEDEVV
//
