ID A0A2P8B3C3_9ACTN Unreviewed; 391 AA.
AC A0A2P8B3C3;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:PSK67217.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:PSK67217.1};
GN Name=adh_1 {ECO:0000313|EMBL:PSK67217.1};
GN ORFNames=B0E53_00851 {ECO:0000313|EMBL:PSK67217.1};
OS Micromonospora sp. MH33.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1945509 {ECO:0000313|EMBL:PSK67217.1, ECO:0000313|Proteomes:UP000240342};
RN [1] {ECO:0000313|EMBL:PSK67217.1, ECO:0000313|Proteomes:UP000240342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MH33 {ECO:0000313|EMBL:PSK67217.1,
RC ECO:0000313|Proteomes:UP000240342};
RA Thatcher L.F., Myers C.A., O'Sullivan C.A., Roper M.;
RT "Draft genome sequences of Micromonospora sp. MH33 and MH99.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK67217.1}.
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DR EMBL; MUYZ01000012; PSK67217.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8B3C3; -.
DR OrthoDB; 3399630at2; -.
DR Proteomes; UP000240342; Unassembled WGS sequence.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08283; FDH_like_1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:PSK67217.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000240342};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..150
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 197..266
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 391 AA; 41852 MW; 9883DD1DF1998204 CRC64;
MKANCWVAPN RVAVEEVPDP TILNPRDAVV KVTSAAICGS DLHLLDGLIP AMKRGDVLGH
EFMGEIVELG SGARDGLRVG DRVVVGFPIA CGDCASCQRG LYSVCENSNP NAAIAETAMG
HAPAGIFGYS HLLGGYAGGQ AEYVRVPYAD VGALKIEDGL PDEQVLFLSD VLPTGYMAAE
MGDVKPGDVV AVWGAGPVGQ FAAVSAFLLG AEQVVVIDRF PYRLRIARDK AGAETINYEE
TDVLDTLREM TAGRGPDVCI DAVGMEGHHA SAALHAYDRA KQAVKAETDR PHALREAILA
CRNGGTVSAI GAYGGFIDKF PMGSFMNRSL TLRSGQAHVQ RYMRPLLERV SKGEIDPSFI
ITHTMRLDDT PHGYDIFKNK QDDCLKVVLK P
//
