ID A0A2P8B445_9ACTN Unreviewed; 345 AA.
AC A0A2P8B445;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase {ECO:0000313|EMBL:PSK67487.1};
DE EC=2.1.1.302 {ECO:0000313|EMBL:PSK67487.1};
GN Name=aziB2_2 {ECO:0000313|EMBL:PSK67487.1};
GN ORFNames=B0E53_00466 {ECO:0000313|EMBL:PSK67487.1};
OS Micromonospora sp. MH33.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1945509 {ECO:0000313|EMBL:PSK67487.1, ECO:0000313|Proteomes:UP000240342};
RN [1] {ECO:0000313|EMBL:PSK67487.1, ECO:0000313|Proteomes:UP000240342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MH33 {ECO:0000313|EMBL:PSK67487.1,
RC ECO:0000313|Proteomes:UP000240342};
RA Thatcher L.F., Myers C.A., O'Sullivan C.A., Roper M.;
RT "Draft genome sequences of Micromonospora sp. MH33 and MH99.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK67487.1}.
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DR EMBL; MUYZ01000006; PSK67487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8B445; -.
DR OrthoDB; 582216at2; -.
DR Proteomes; UP000240342; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:PSK67487.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000240342};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:PSK67487.1}.
FT DOMAIN 14..96
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 139..323
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 251
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 345 AA; 37789 MW; FE5AD17FBC5F6751 CRC64;
MTVMNESNLT PLPLLQLSSG FSSFKTFAAA VELSLFTRLA DGRTMSVSEA AAEFGLPHRP
ADLLLTACAS LGLLERRGDG YGNTALAEKF LVEGRPYYFG GLVRFYDKRE YPAWDRVLDA
LRTDKPTAWD PEVQDSPFVA EDSQMLQLFW DAMHCISTFT ARALGEVYDF GRHSRLLDVG
GGSGAFPIEL CRHYAHLSAT VYDLPHVCPI ADSKIADAGL SGRITTVTGD FLRDAALPAG
YDVILYSMIM HDWGEDTDRE LLRRAYEALA PGGVVIISEL MLNADRTGPA EAALMGMNML
IETTAGKNYS ETEYMNWLQD AKFSDIRTLP FVAAGANGVV IGVKD
//
