ID A0A2P8CWV1_9ACTN Unreviewed; 843 AA.
AC A0A2P8CWV1;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:PSK89416.1};
GN ORFNames=CLV63_12652 {ECO:0000313|EMBL:PSK89416.1};
OS Murinocardiopsis flavida.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Murinocardiopsis.
OX NCBI_TaxID=645275 {ECO:0000313|EMBL:PSK89416.1, ECO:0000313|Proteomes:UP000240542};
RN [1] {ECO:0000313|EMBL:PSK89416.1, ECO:0000313|Proteomes:UP000240542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45312 {ECO:0000313|EMBL:PSK89416.1,
RC ECO:0000313|Proteomes:UP000240542};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK89416.1}.
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DR EMBL; PYGA01000026; PSK89416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8CWV1; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000240542; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240542};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..412
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 96..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 158..185
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 88035 MW; 70C982191D537E53 CRC64;
MAEFLYRLGR ASAHRARTVI AIWLALMVAA GTAFFLFAGE LEDSFSIPGT PTDQVNQTLK
QEFSGMGGGA GTVVYQTEDG SAFTKEQRDA IADRAEKAAE KDGVEDVVDP FATEQDRAEQ
TEKLDDGRAE IKDGREKLED GQKKLDAGRD QAESAGMLDQ VEDGLDAQQA EIDNNRDTLD
EESRKLEQGA DLTKMSAELR SVSKDDSTAL VHVAFTDSQE EVSQATREDV MAVFDDAPVA
GTSVDFANDI AMAMPTLVSP AEVIGLIVAG VVLVVMLGTF IGAGLPILTA LVGVGIATLT
AMSLSDVLEM ASVTPILGLM LGLAVGIDYA LFIVHRHRRQ LKEGIGVAES IGLANGTAGN
AVVFAGTTVL IALLGLNLTG IGFLGLMGSV GAIAIAIAVL IAVTLVPALL SLVGMRILAR
RERDRMGRDA AGGRGAAHAA GAHLRQMSTV RAMGRAAVAV IALGVIALPA LDLRTGMPDG
SSEPAESTQH RAYTAVADKF GDGQNGPLLV TANLPGGPTE ESAKENAADA QFQVAEKLYA
HDDVAAVAPI GVSDDHTLGI FQVVPEGGPA SASTEELVHT FRDMEPVHGL GPLGVAGMAS
GNVDISETLS GALPTYLTVV VGLSLVILLL VFRSVFVPVV ATLGFILSYF AALGGVVAVY
QWGWLGGLIG LDTPGPVLNF LPTLLAGILF GLAMDYMLFI GTGMREAYVH GAPARLAVVQ
GFRAGRAVVT AAAIIMISIF GGFVFSETMM ISSVGFALAF GVLLDAFVVR MLLIPALMHL
AGNAAWWLPR WLDRLLPDID VEGAALERAH TAEPAAAPAD RTPDPADEPS PDGLDDTVAS
GRR
//
