ID   A0A2P8D236_9ACTN        Unreviewed;      1102 AA.
AC   A0A2P8D236;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=HAE1 family hydrophobic/amphiphilic exporter-1 {ECO:0000313|EMBL:PSK91290.1};
GN   ORFNames=CLV63_12016 {ECO:0000313|EMBL:PSK91290.1};
OS   Murinocardiopsis flavida.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Murinocardiopsis.
OX   NCBI_TaxID=645275 {ECO:0000313|EMBL:PSK91290.1, ECO:0000313|Proteomes:UP000240542};
RN   [1] {ECO:0000313|EMBL:PSK91290.1, ECO:0000313|Proteomes:UP000240542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45312 {ECO:0000313|EMBL:PSK91290.1,
RC   ECO:0000313|Proteomes:UP000240542};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PSK91290.1}.
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DR   EMBL; PYGA01000020; PSK91290.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2P8D236; -.
DR   OrthoDB; 3306666at2; -.
DR   Proteomes; UP000240542; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 2.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF0; SWARMING MOTILITY PROTEIN SWRC; 1.
DR   Pfam; PF00873; ACR_tran; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240542};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        376..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        501..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        903..922
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        929..949
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        955..980
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1001..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1034..1056
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          252..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1063..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1063..1091
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  114645 MW;  71DB2C4C2B1C053B CRC64;
     MSRLAKLSLG NRALILLITL AAIVFGLIAT TSAKRELMPS LELPMVMVSA QYQGASPEVV
     ENEVTEPLEQ AVKGVPGITS YTSTSSNGST SITAEFDYGD ETEDVVRSIT QAVDQSKATL
     PDDVEPNVQA FSFDDIPVVM LAAGAEDDEQ KLAEPLQEQV VPELESIDGV RAAQVTGVRE
     STVAITPDED ELEDEGLTSA DLTGALQASG AMVPGGDITE DGRTLTVTTG GKLESLDDVK
     NIWLMPGGGG AGAGGGEAQG GGAAGGAAGG AAAGGAAGGA GAMAPAAPSD PVQLKDVAKV
     KLQPDEASSI TRTDGKPSLG IMVTKTPEGN TVEISEAVQQ KLDDLKPLLP AGAEVTVVFD
     QAPFINESIV AMGEEGLLGL GFAIIIILVF LLSIRSTIVT AISIPVSLLV AMIGMQAFEY
     SLNILTLGAL TIAIGRVVDD SIVVLENIKR HMSYGEERYA SVYTGVREVA AAITSATLTT
     VAVFLPMGFV GGEVGELFRP FAVTVSIALG ASLLVSLTII PVLCYWFMRP RIVPPEELER
     VKAEEYQREL RTPLQRIYLP VIRWATRFRL TTIAVAVLIF AGTVYLAVGG FLKTNFLGDQ
     GQNTHQITQE LPISTSLAEA DKEAEKIEDA LSGLSWVESY QASLGGGAGG EAAAMGPMGG
     GGAATTNTYT VTTDPDGDQA VYAERLREAL ESVDTEAEPQ VAAAGGTGTS NLQVEVKAEN
     NEDLEKAAND VEDVVRDIPG AADVQNSIAA AQPALEVRVK GEKAADEGLS EGQVAQAVSD
     AFSGADVGKA TVDDVQRDMV VRLEDKPGSA KELRNLEIAT PAGDNETVDL SDVAVVDEVK
     QAPELSRSGG VSTATIEATP TADDLGSVTA ELTQKLDTVD LPDGATASLG GVSSDQNEAF
     TQLGIAMLAA IAIVYLIMVA TFKSLMQPLI LLVSIPFAAT GALGLLWLTG VPLGLPSMIG
     LLMLIGVVVT NAIVLIDLIN QYREDGMELR EAVVEGSRHR LRPILMTSLA TMGALTPMAL
     GITGGGAFIS QPLAVVVIGG LVTSTLLTLV LVPVLYTMSE GRKERRAAKR AAKREAKIEA
     ARAERQEQDA ERAAAGTGGQ DS
//