ID A0A2P8DB24_9BACT Unreviewed; 1160 AA.
AC A0A2P8DB24;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=B0I18_101574 {ECO:0000313|EMBL:PSK94418.1};
OS Taibaiella chishuiensis.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Taibaiella.
OX NCBI_TaxID=1434707 {ECO:0000313|EMBL:PSK94418.1, ECO:0000313|Proteomes:UP000240572};
RN [1] {ECO:0000313|EMBL:PSK94418.1, ECO:0000313|Proteomes:UP000240572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.12700 {ECO:0000313|EMBL:PSK94418.1,
RC ECO:0000313|Proteomes:UP000240572};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSK94418.1}.
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DR EMBL; PYGD01000001; PSK94418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8DB24; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000240572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000240572}.
FT DOMAIN 619..780
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 801..955
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1160 AA; 132970 MW; 4E05C44B4390269E CRC64;
MNLQTLLGIY LNDNRLKQLA AGLSLPEPKM RISLRNLRGS SVNFIATAVW QQAETNHVFV
LNDREEAAYF HNDLESLTQA LDICFFPDSF KKTGVYTGLN SSHIMLRTEA LAHLSESKTR
SGANVKRKVL VTYPEALFEK VVNAQSLSSN MIHIKTSEIL KVDELMKRFV ELGFKREDFV
YEPGQFAMRG GILDIYSFGN EHPYRIELFG NEVDSIRIFN PETQLSERKL LQVSILPNIE
TRFETQEKIS LLDYLPEHTT FWFKDLDFTL GKLSKMELDL AEKLPQGNIT AVEQEEQWLK
ELAADDFEIA SEWRDKLQHK HIIEWFATAD KNESTGSTEE TKSIADRERE RNNVIDLSTF
KPINFSAYQP VSFSTEHQPV FNRNFEILTG NLKRYIDAGY TPYIFAENAK QLERLRTIFE
DSNAQINFVP IPVSLSKGFI DHEHKILAYT DHQIFQRYHK YRIKQAYSKG KAITLKALKE
LQPGDFVTHI DHGVGKYSGL QKIEVNGNMQ EAVRILYRDN DVLYVNINSL HKISKYTGKE
GTVPKVNKLG SDAWEKLKNK TKKQVKDIAA DLIRLYARRK ASPGFAHSPD SYIQTELEAS
FFYEDTPDQS KATADVKRDM EAPAPMDRLV CGDVGFGKTE IAVRAAFKTV GDSKQAAILV
PTTILAYQHY QTFKERLKDF PANVDFINRF KSAKEKKETL KRVEEGKVDI IIGTHALLGK
EVKFKDLGLL IIDEEQKFGV SAKEKLRERK ANVDTLTLTA TPIPRTLQFS LMNARDMSII
NTPPPNRQPV HTEVMGFDEA TIRDAIYFET ERGGQVYFVH NRVQSLPAMA EKLRELCPDL
EIGMAHGQME GSKLEKALLD FINYKYDVLC CTNIVESGVD ISNANTIIIN NAHHFGLSDL
HQLRGRVGRN NKKAFCYLVA PSMITLPNDS RKRLQTLEQF NELGSGFQIA MRDLDIRGAG
NILGGEQSGF IAEIGFEMYQ KILAEAMHEL RSTDFKEVFA EEMDRKKDFV TDCTIDTDLE
ILIPDSYIEN ITERLSLYTQ LDDIEDEAEL QLFEEELRDR FGPIPAQVND LFRALRCRKM
AKELGFEKLI LKNEQMRLYF VSNPDSPYFE SETFNYIMQY IQTQTNNARL KQVGKNFMLI
VDHIKSMSDV EWFLQGMTKK
//
